Spectrophotometric Determination of Nitroxoline in Medicines Using the Response Surface Methodology

IF 0.4 Q4 MULTIDISCIPLINARY SCIENCES
R. Bakeeva, S. Garmonov, V.D. Osipova, K.V. Chernyj, S.Yu. Mamykina, V. Sopin
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引用次数: 0

Abstract

It was shown by the conductometric study that the formation of micelles in the cetyltrimethylam¬monium bromide (CTAB) – dimethylsulfoxide (DMSO) – water system occurs at higher critical micelle concentrations (CMC) than in the CTAB – water system. The solubilization of nitroxoline in this system upon reaching the CMC was determined by the spectrophotometric method. The Box–Behnken design was used to obtain systems with the highest light absorption of nitroxoline, depending on the CTAB concentration, the acidity of the pH medium, and the proportion of DMSO when searching for the optimal matrix. A sensitive and selective technique suitable for micellar media and spectrophotometric analysis was developed using the response surface methodology for the determination of nitroxoline in medicines.
响应面法分光光度法测定药物中的硝基喹啉
电导研究表明,十六烷基三甲基溴化铵(CTAB) -二甲基亚砜(DMSO) -水体系的胶束形成发生在比CTAB -水体系更高的临界胶束浓度(CMC)下。用分光光度法测定了硝基喹啉在该体系中到达CMC后的增溶作用。采用Box-Behnken设计,根据CTAB浓度、pH介质的酸度和DMSO的比例寻找最佳基质,获得对硝基喹啉光吸收最高的体系。建立了一种适用于胶束介质和分光光度分析的灵敏、选择性的响应面法测定药物中硝基喹啉的方法。
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来源期刊
CiteScore
0.70
自引率
0.00%
发文量
0
审稿时长
17 weeks
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