Novel Gene Therapies Technology for Spinal Cord Injury (SCI) Therapy: Efficient Direct Lineage Reprogramming

Abstract

What is known and objectives: Spinal Cord Injury (SCI) is defined for the last few decades as patients getting wheelchair bound and under medication for a lifetime [1]. Medical battery for SCI is very limited which often results in heightened frustration for the caregivers who land up with no solid solution to the condition. However, in recent times due to the huge volume of research, neuroscience has progressed massively through GT offering better insight and high hopes of neural regeneration and functional rehabilitation [2]. As GT technology becomes more popular as an emerging therapeutic method, many studies using a manufactured virus (AAV, retro, adeno, lenti) are opening up promising research avenues [3-5]. In this review, we dealt with Direct Lineage Reprogramming (DLR) technology for a novel GT method for SCI patients.