Generate Better Hypertrophic Cardiomyopathy Model Using Induced Pluripotent Stem Cells and Crispr/Cas9

Abstract

Hypertrophic cardiomyopathy (HCM) has been a heart disease causing the most sudden cardiac death among young people in US, and this problem still remains unsolved. In this paper, we will reintroduce HCM and discuss the methods that could be used to treat it. Many other studies, involving animal models; Induced pluripotent stem cells (iPSCs); CRISPR/Cas9, would also be mentioned to understand the disease better. Many techniques are useful in curing HCM. One of the helpful mechanisms would be iPSCs, which helps reprogramming a patient's somatic cells, differentiating them into cells needed for the study. Due to different background issues, CRISPR/Cas 9 would then be added to generate isogenic iPSCs. Combining both mechanisms would help in comparing patient's HCM iPSCs and control iPSCs, which provides us more information about pathogenic background of HCM and further assists in the process of curing HCM.