Ibuprofen/β-CD complexation by controlled annealing of their mechanical mixture

Abstract

Ibuprofen/β-cyclodextrin complex was formed applying a modified melting method, consisting in melting only the drug in the mechanical mixture of ibuprofen and β-cyclodextrin. The ibuprofen inclusion into β-CD was monitored by differential scanning calorimetry after initial release of the water molecules from the CD cavity and was proved by X-ray diffraction and FTIR analyses. Keywords: β-cyclodextrin, ibuprofen, inclusion complex, melting method