The role of medications misused for body weight gain on some fertility hormones concentration of female rabbits.

Abstract

The objective of the present work was to study the effects of some drugs misused by Sudanese women as body weight gain drugs on some fertility hormones concentration of female rabbits. Sixteen female rabbits were procured from local markets of Elnuhod localality, West Kordofan state. A randomized complete block design with three replicates was used; the treatments consisted of two drugs i.e., dexamethasone, cyperoheptadine and their combination administered orally with doses of 0.9 mg/kg of body weight with drugs two times a day for 45 days. Follicle stimulating hormone, luteinizing hormone, and prolactin were measured. The results showed that the medication used affects the levels of fertility hormones. The results showed that the level of FSH due to drugs decreased with time and the lowest level of the hormone was shown by the combination and dexamethasone and the values were (2.32 and 2.51 IU/L, respectively), while cyperoheptadine recorded a level of (2.75 IU/L) as highest value with significant differences as compared to other two treatments. The results showed that prolactin hormone increased with time by all drugs used and their combinations at the end of the experiment period, and there was no significant difference between the drugs in their effect on hormone level, physician and pharmacist should be consultant before using these drugs to avoid the adverse effects is needed as recommended point of view, effects of drugs on serum total cholesterol, triglyceride, high-density lipo-protein, low density lipo- protein and very low density lipo- protein are also recommended for future work.