Evaluation of Trans-Resveratrol as a Treatment for Periodontitis

Tracey Lynn Harney
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引用次数: 1

Abstract

Periodontitis is a globally prevalent inflammation-mediated disease that can result in varying degrees of destruction to the tissues supporting the teeth. The microbial pathogenic dysbiosis, oxidative stress, and deregulated inflammation, found in patients with periodontitis, make it a multifaceted condition that is difficult to fully resolve. Further to this, periodontitis has been associated with other systemic inflammatory conditions. Trans-resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a plant-derived molecule present in many foods, which have been shown to exhibit antimicrobial, antioxidant, anti-inflammatory, and regenerative properties. However, trans-resveratrol has been reported to have physicochemical shortcomings, which make its clinical translation a challenge. This review outlines a critical analysis of identified samples from the scientific literature that was conducted to assess the potential of RES as a viable therapeutic for periodontitis. The potential for the improvement of the limiting pharmacological profile of trans-resveratrol via nanoformulation is also explored.
反式白藜芦醇治疗牙周炎的疗效评价
牙周炎是一种全球流行的炎症介导的疾病,可导致不同程度的破坏组织支持牙齿。在牙周炎患者中发现的微生物致病性生态失调、氧化应激和失控的炎症,使其成为一种难以完全解决的多方面疾病。除此之外,牙周炎还与其他全身性炎症有关。反式白藜芦醇(3,5,4 ' -三羟基反式二苯乙烯)是一种植物来源的分子,存在于许多食物中,已被证明具有抗菌、抗氧化、抗炎和再生特性。然而,据报道,反式白藜芦醇具有物理化学缺陷,这使其临床翻译成为一项挑战。本综述概述了对科学文献中已识别样本的关键分析,以评估RES作为牙周炎可行治疗方法的潜力。还探讨了通过纳米配方改善反式白藜芦醇的限制性药理学特征的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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