Immunity is Affected by Viral Cancer- A Review

Abstract

ABSTRACT- T cell responses that recognize and eradicate cancer cells. However, elimination of cancer by T cells is only one step in the Cancer-Immunity Cycle, which manages the delicate balance between the recognition of onself and the prevention of autoimmunity. Identification of cancer cell T cell inhibitory signals, includingPD-L1, has prompted the development of a new class of cancer immunotherapy that specifically hindersmmune effector inhibition, reinvigorating and potentially expanding preexisting anticancer immune re-sponses. The presence of suppressive factors in the tumor microenvironment may explain the limited activityobserved with previous immune-based therapies and why these therapies may be more effective in combi-nation with agents that target other steps of the cycle. Emerging clinical data suggest that cancer immuno-therapy is likely to become a key part of the clinical management of cancer Keywords- Immunity, Virus ,Cancer, Human Papillomavirus,Therapy.