The role of vagus nerve in sepsis induced by acute cholangitis and its possible mechanism

Abstract

Acute cholangitis (AC) is a morbid condition with acute inflammation and infection in the bile duct, which meets the diagnostic criteria of sepsis 3.0. AC mortality rate is high without treatment in time, and it is a main disease in emergency department. The occurrence and development of sepsis depend on the regulation of nerve and immunity system, and cholinergic anti-inflammatory pathway plays an important role in connecting nerve and immune function. The biliary tract is innervated by vagus nerves, which can be excited when the pressure increases in the biliary tract. The research on the role of vagus nerves and cholinergic anti-inflammatory pathway (CAIP) in sepsis caused by acute cholangitis is more advantageous than other infectious diseases. Key words: Vagus nerve; Acute cholangitis; Sepsis