Effect of Solvents on the Fluorescent Spectroscopy of BODIPY-520 Derivative

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-06-22 DOI:10.1155/2022/1172183

Buthaina Kamel, Moustafa Sayem El-Daher, W. Bachir, A. Ibrahim, S. Aljalali

引用次数: 0

Abstract

Photodynamic therapy (PDT) is a selective and minimally invasive technique for the treatment of tumors. It includes three components such as photosensitizer, light, and molecular oxygen. The purpose of this work is to investigate the effect of the solvents such as methanol, ethanol, acetone, and water on fluorescent spectroscopy produced by one of the BODIPY derivatives in turbid media. A 520 nm laser diode is used for exciting one of the BODIPY derivatives as a photosensitizer in tissue-like optical phantoms. Results show that the photosensitizer studied without absorption and scattering components in the methanol and ethanol solvent has a prominent fluorescence peak at 600 nm, whereas acetone solvent has a prominent fluorescence peak at 546 nm. Experimental results reveal that when absorption and scattering components are present in addition to the studied solvents, the characteristic fluorescence intensity peak is red-shifted to 678 nm.

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溶剂对BODIPY-520衍生物荧光光谱的影响

光动力疗法(PDT)是一种选择性的、微创的肿瘤治疗技术。它包括光敏剂、光和分子氧三种成分。本研究的目的是研究甲醇、乙醇、丙酮和水等溶剂对一种BODIPY衍生物在混浊介质中产生的荧光光谱的影响。520nm激光二极管用于激发BODIPY衍生物中的一种，作为组织样光学幻影的光敏剂。结果表明，不含吸收和散射组分的光敏剂在甲醇和乙醇溶剂中在600 nm处有一个突出的荧光峰，而丙酮溶剂在546 nm处有一个突出的荧光峰。实验结果表明，当吸收和散射组分与所研究的溶剂同时存在时，特征荧光强度峰红移至678 nm。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.