Antibacterial and Enzyme Inhibition Study of Hydrazone Derivatives Bearing 1, 3, 4- Oxadiazole

Abstract

The antibacterial and lipoxygenase enzyme inhibition activities of two series of compounds have been investigated in the presented work. The 4-methyl/hydroxy benzoic acids (1a & 1b) were used as starting materials to prepare corresponding esters (2a & 2b), hydrazides (3a & 3b), 5-(4-methylphenyl/4-hydroxyphenyl)-1,3,4-oxadiazol-2-thiols (4a & 4b), S-substituted esters (5a & 5b) and acetohydrazides (6a & 6b). The acetohydrazones, 8a-i & 9a-i, were synthesized by stirring 6a & 6b with mono(di)substituted phenylcarboxaldehydes (7a-i) in methanol. The data of IR, 1 H-NMR and EIMS spectral techniques well confirmed the structural formulae of synthesized compounds. The molecules of 4-methyl series rendered the better results than those of 4-hydroxy series.