Changes in Serum Concentration of VEGF Angiogenesis Factor and I-FABP Intestinal Barrier Biomarker in Different Outcomes of Treatment of Patients with Duodenal Injury

Abstract

Background and Aim of Study: Abdominal injuries, due to a blunt and penetrating mechanism of origin, have a marked mortality rate from hemorrhage and sepsis. Diagnosis and treatment of damage to the duodenum is one of the complex problems of emergency abdominal surgery, although they are rare and account for 0.2-0.6% of all trauma patients and 1-4.7% of all abdominal injuries . The aim of the study: to research the dynamics of the concentration in the blood of the factor of VEGF angiogenesis and a marker of damage to the digestive tract I-FABP in adults with various postoperative consequences of trauma to the duodenum. Studies were conducted in 60 patients (mean age 36 (18-73) years) with isolated and multiple traumatic injuries of duodenum ≥ grade II according to AAST criteria operated in the period 2006-2019. Results: The level of I-FABP was higher in patients who had complications and needed reoperation and correlated with the severity of the patients’ condition, and according to Spearman’s criterion the comparisons were valid in all three periods of study (p=0.002, p=0.000, p=0.001). Conclusions: Serum I-FABP level is a valuable, convenient, objectively early predictor of digestive injury in duodenal injury due to suppression of vascular proliferation, decrease in endothelial permeability, which is determined by the dynamics of VEGF changes in the treatment of this category of patients, and depends on their condition and severity, the presence of complications that require repeated surgery.