Research progress of obstructive sleep apneahypopnea syndrome and coronary heart disease

Chunlei Shao, Wenjiao Jiang, Linna Jiang, H. Yue
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Abstract

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a disorder of recurrent hypoxia and daytime sleepiness caused by airway collapse during sleep.Obstructive sleep apnea-hypopnea syndrome is closely related to cardiovascular diseases such as hypertension, arrhythmia, coronary atherosclerotic heart disease and heart failure.OSAHS plays an important role in promoting the occurrence and development of cardiovascular diseases.Currently, OSAHS as an important risk factor of coronary atherosclerotic heart disease is gradually paid attention to.This article reviews the pathogenesis of OSAHS induced coronary heart disease, the relationship between OSAHS and coronary artery stenosis, the adverse prognosis of OSAHS combined with coronary heart disease and the effect of continuous positive airway pressure on the prognosis of these patients. Key words: Sleep apnea, obstructive; Coronary artery disease; Coronary stenosis; Continuous positive airway pressure; Pathogenesis
阻塞性睡眠呼吸暂停综合征与冠心病的研究进展
阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种由睡眠时气道塌陷引起的反复缺氧和日间嗜睡的疾病。阻塞性睡眠呼吸暂停低通气综合征与高血压、心律失常、冠状动脉粥样硬化性心脏病、心力衰竭等心血管疾病密切相关。OSAHS在心血管疾病的发生发展中起着重要的促进作用。目前,OSAHS作为冠状动脉粥样硬化性心脏病的重要危险因素逐渐受到重视。本文就OSAHS诱发冠心病的发病机制、OSAHS与冠状动脉狭窄的关系、OSAHS合并冠心病的不良预后以及持续气道正压对患者预后的影响等方面进行综述。关键词:睡眠呼吸暂停;阻塞性;冠状动脉疾病;冠状动脉狭窄;持续气道正压;发病机理
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