Could CAR-T cell therapy be promising agent in acute lymphoblastic leukemia?

Mansoura Veterinary Medical Journal Pub Date : 2022-04-01 DOI:10.21608/mjmu.2021.103500.1048

Omar khafagy, S. El-Ashwah, Ashraf M Shoma

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Abstract

Postoperative anal pain is one of the main adverse effects of surgical treatment of benign anorectal diseases and remains a distressing problem, for both patients and physicians. Postoperative pain control is important yet it remains an unresolved issue which causes patient dissatisfaction and negatively impact quality of life. This review article studied the analgesic effect of topical and oral metronidazole after benign anorectal surgery. Seven studies used oral metronidazole and six used topical metronidazole. The studies showed that post operative pain score of patients who had metronidazole by either route was significantly less than those in comparison groups. The pain score decreased at all the time points for both oral and topical metronidazole. Overall, the analgesic effect of oral metronidazole was inconsistent among published studies. When topical and oral metronidazole were compared the post operative pain score and analgesic consumption were lower in topical metronidazole than the oral group Mansoura Medical Journal (Official Journal of Mansoura Faculty of Medicine) pISSN: 1110-211X; eISSN: 2735-3990

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CAR-T细胞疗法能成为治疗急性淋巴细胞白血病的有效药物吗?

术后肛门疼痛是良性肛肠疾病手术治疗的主要不良反应之一，对患者和医生来说都是一个困扰的问题。术后疼痛控制很重要，但它仍然是一个未解决的问题，引起患者的不满和负面影响生活质量。本文综述了良性肛肠手术后局部和口服甲硝唑的镇痛效果。七项研究使用口服甲硝唑，六项研究使用外用甲硝唑。研究显示，两种治疗方式下甲硝唑组患者术后疼痛评分均显著低于对照组。口服和外用甲硝唑的疼痛评分在所有时间点均下降。总的来说，口服甲硝唑的镇痛效果在已发表的研究中是不一致的。比较外用和口服甲硝唑组术后疼痛评分和镇痛药用量，外用甲硝唑组低于口服组。曼苏拉医学杂志(Mansoura Medical Journal of Mansoura Faculty of Medicine) pISSN: 1110-211X;eISSN: 2735 - 3990

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Mansoura Veterinary Medical Journal

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