Developing a Standardized Review Process of Pharmacogenomics Resources for Psychotropic Medications

Q4 Pharmacology, Toxicology and Pharmaceutics

Current Pharmacogenomics and Personalized Medicine Pub Date : 2021-06-03 DOI:10.2174/1875692118666210603155248

Maja Stoneberg, Natasha J. Petry, C. Grindeland, Monte Roemmich, Amanda Massmann, Jordan F Baye, April Schultz

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引用次数: 0

Abstract

The impact of personalized medicine is potentially enormous, but the genetic results are often difficult to integrate into health settings. A number of research studies are emerging to aid in translating pharmacogenomics into clinical practice. We aimed to create a standardized process to guide the implementation of dose adjustment recommendations into the electronic health record (EHR). Monographs were created for selected drug-gene pairs allowing for standardized review of available evidence. A scoring template was developed to assess whether the evidence presented in the drug monograph qualified said drug-gene pair for Clinical Decision Support (CDS) within the EHR. Of nine medications reviewed, only one drug-gene pair qualified for a CDS proposal to the institution’s governing pharmacogenomics committee. This project resulted in the development of a standard process for review to analyze pharmacogenomics literature allowing for CDS proposals.

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开发精神药物药物基因组学资源的标准化审查程序

个性化医疗的影响可能是巨大的，但遗传结果往往难以整合到健康环境中。许多研究正在涌现，以帮助将药物基因组学转化为临床实践。我们的目标是创建一个标准化的过程来指导剂量调整建议在电子健康记录(EHR)中的实施。为选定的药物基因对创建了专著，允许对现有证据进行标准化审查。开发了一个评分模板来评估药物专著中提供的证据是否符合EHR中临床决策支持(CDS)的药物-基因对。在审查的九种药物中，只有一种药物基因对符合向该机构的药物基因组学委员会提交CDS提案的条件。该项目导致了一个标准流程的发展，用于审查分析药物基因组学文献，允许CDS提案。

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来源期刊

Current Pharmacogenomics and Personalized Medicine Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： Current Pharmacogenomics and Personalized Medicine (Formerly ‘Current Pharmacogenomics’) Current Pharmacogenomics and Personalized Medicine (CPPM) is an international peer reviewed biomedical journal that publishes expert reviews, and state of the art analyses on all aspects of pharmacogenomics and personalized medicine under a single cover. The CPPM addresses the complex transdisciplinary challenges and promises emerging from the fusion of knowledge domains in therapeutics and diagnostics (i.e., theragnostics). The journal bears in mind the increasingly globalized nature of health research and services.