Mahsa Zarei, H. Du, A. Nassar, Rachel E Yan, K. Giannikou, Sneha Johnson, H. Lam, E. Henske, Yubao Wang, Tinghu Zhang, J. Asara, D. Kwiatkowski
{"title":"Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion","authors":"Mahsa Zarei, H. Du, A. Nassar, Rachel E Yan, K. Giannikou, Sneha Johnson, H. Lam, E. Henske, Yubao Wang, Tinghu Zhang, J. Asara, D. Kwiatkowski","doi":"10.1084/jem.20190251","DOIUrl":null,"url":null,"abstract":"Tuberous sclerosis complex (TSC) is a genetic disorder in which tumors develop due to TSC1/TSC2 loss and activation of mTORC1. Zarei et al. show that TSC tumors are sensitive to CDK7 inhibition, which reduces expression of NRF2 and glutathione synthetic genes, leading to glutathione depletion and ROS-mediated cell death.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"216 1","pages":"2635 - 2652"},"PeriodicalIF":0.0000,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20190251","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15
Abstract
Tuberous sclerosis complex (TSC) is a genetic disorder in which tumors develop due to TSC1/TSC2 loss and activation of mTORC1. Zarei et al. show that TSC tumors are sensitive to CDK7 inhibition, which reduces expression of NRF2 and glutathione synthetic genes, leading to glutathione depletion and ROS-mediated cell death.
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