EFFECTS OF STEM-BARK EXTRACT OF OKOUBAKA AUBREVILLIE ON SOME VISCERAL ORGANS OF WISTAR RATS

African Journal of Traditional, Complementary and Alternative Medicines Pub Date : 2018-05-30 DOI:10.21010/AJTCAMV15I3.7

Achukwu U. Peter, Ufelle A Silas, Onyekwelu C Kenechukwu, Amadi N Millicent, A. O. Ngozika, Amadi N Francis

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引用次数: 1

Abstract

Background: Over the past two decades, there has been a tremendous increase in the use of herbal medicine; however, these herbs have not been properly evaluated to ascertain their effect on the body organs. Materials and Methods: Effects of stem bark extract of Okoubaka aubrevillie on some visceral organs were investigated in Wistar rats. For acute toxicity testing, Wistar rats (n=16), grouped into 4, (A-D) orally received graded doses of Okoubaka aubrevillie extract and deaths recorded within 24 hours. For sub-acute study, Wistar rats (n=20) grouped into 5, (A-E) orally received graded doses of Okoubaka aubrevillie extract for 31 days. Blood samples were collected from each rat through retro-orbital puncture for biochemical analysis. The liver, kidney and stomach were excised and processed for light microscopy. For toxin inhibition studies, Wistar rats (n=24) grouped into 6 (A-F), were used. Groups A-C and D-F orally received graded doses of Dichlorvos. Groups A-C further received Okoubaka aubrevillie extract while D-F received water and death records observed. Results: For acute toxicity testing, lethal dose (LD50) of 7500 mg/kg body weight was obtained from the inverse of the log-dose. Sub-acute studies revealed significantly elevated mean body weight in group A (210 ± 4.5 gram) compared to control (178 ± 5.0 gram), (p

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黑藤茎皮提取物对wistar大鼠内脏器官的影响

背景:在过去的二十年里，草药的使用有了巨大的增长;然而，这些草药还没有得到适当的评估，以确定它们对身体器官的影响。材料与方法:以Wistar大鼠为实验对象，研究了大黄茎皮提取物对内脏器官的影响。急性毒性试验:Wistar大鼠(n=16)，分为4组(A-D组)，口服分级剂量的大鼠黄刺草提取物，记录24小时内死亡情况。亚急性研究中，Wistar大鼠(n=20)，每组5只，(A-E)口服分级剂量的大鼠黄刺草提取物31天。每只大鼠经眶后穿刺采血进行生化分析。取肝、肾、胃进行光镜处理。毒素抑制实验采用Wistar大鼠(n=24)，每组6只(A-F)。A-C组和D-F组口服敌敌畏分级剂量。A-C组继续给予奥古巴卡提取物，D-F组给予水并观察死亡记录。结果:急性毒性试验中，由对数剂量倒数得到致死剂量(LD50)为7500 mg/kg体重。亚急性研究显示，与对照组(178±5.0克)相比，A组的平均体重显著升高(210±4.5克)

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来源期刊

African Journal of Traditional, Complementary and Alternative Medicines 医学-全科医学与补充医学

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The “African Journal of Traditional, Complementary and Alternative Medicines (AJTCAM)” is a peer-reviewed, multidisciplinary, international, scientific Open Access Journal that provides publication of articles on phytomedicines, ethnomedicines and veterinary ethnomedicines. The journal is published by a Non-Governmental Organization (NGO) known as “African Traditional Herbal Medicine Supporters Initiative (ATHMSI)”. The Journal welcomes submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published approximately two-to-three months after acceptance