Development of Drugs for Treatment of Mortellaro’s Disease in Cattle

N. Belyakova, A. Kovalenko, Yuliya Bodrova
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引用次数: 1

Abstract

The root cause of premature culling of animals from the herd as a result of diseases and injuries is a lesion of distal portions of limbs of an infectious etiology, which include Mortellaro’s disease. Mortellaro's disease affects up to 60 percent of the cattle in Russia. BelNano was developed, consisting of liposomal fractions and nanoparticles of silver and copper distributed in its volume. The surface of the nanoparticles has been specially modified to provide high efficiency on the skin and keratinized tissues. Pathogens that were found in impression smear and Fusobacterium necrophorum, Treponema, Borellia grown on nutrient media, which were sensitive to the active components of the BelNANO, ensuring their inactivation by action on the cell wall were revealed in the studied animals with Motellaro's disease. In experiments on the study of effectiveness of the BelNANO for the prevention and treatment of skin and skin coverings of the distal portion of limbs in Mortellaro’s disease, 89 percent therapeutic efficacy was established, providing not only a high bactericidal and bacteriostatic effect on infectious agents, but also high regenerative properties of the drug, expressed in epithelization and the appearance of granulation tissue. Keywords—skin and skin lesions, Mortellaro’s disease, Cu and Ag nanoparticles, lameness, drug for the treatment of interdigital cleft, cattle
牛莫特拉罗病治疗药物的研究进展
由于疾病和损伤而过早扑杀畜群动物的根本原因是肢体远端部位的感染性病变,其中包括Mortellaro病。Mortellaro病影响了俄罗斯60%的牛。开发了BelNano,由分布在其体积中的银和铜的脂质体和纳米颗粒组成。纳米颗粒的表面经过特殊修饰,可以在皮肤和角质化组织上提供高效率。在Motellaro病的研究动物中发现,在印象涂片和营养培养基上生长的坏死梭杆菌、密螺旋体、borelia中发现的病原体对BelNANO的活性成分敏感,并通过作用于细胞壁来确保它们的失活。在研究BelNANO预防和治疗Mortellaro病肢体远端部分皮肤和皮肤覆盖物的有效性的实验中,建立了89%的治疗效果,不仅提供了对感染性病原体的高杀菌和抑菌作用,而且还提供了药物的高再生特性,表现在上皮和肉芽组织的外观上。关键词:皮肤和皮肤病变,莫特拉罗氏病,纳米铜和银,跛行,治疗指间裂的药物,牛
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