Association of hsCRP with Serum Creatinine in Type 2 Diabetic Patients at Tertiary Care Hospital

Journal of Current and Advance Medical Research Pub Date : 2023-08-07 DOI:10.3329/jcamr.v9i2.67815

M. Aziz, Tohfa E Ayub, F. Islam, F. Ahmed, N. Jahan, N. Ferdous

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Abstract

Background: High-sensitive C-reactive protein (hs-CRP) is a marker of inflammation. CRP may play a significant role as a predictor of inflammation in nephropathy and chronic kidney disease. Objective: The aim of the present study was to estimate hs-CRP levels and serum creatinine levels among type 2 diabetes mellitus patients and to determine association between them. Methodology: This was an analytical, quantitative, hospital-based study performed on type 2 diabetic patients and was conducted at the Department of Biochemistry of BIRDEM General Hospital, Dhaka, Bangladesh. It was analyzed serum concentrations of hs-CRP, serum creatinine, serum glucose and family history of the patients. Results: This observational study showed that a greater number of diabetics had high serum creatinine level (41% vs 59%). 67.6% of study population had moderate to high level of hsCRP. hs-CRP was found significantly higher in diabetics with renal impairment (1.66±0.86 vs. 7.01±3.44, p<0.001). Serum creatinine had positive (r=0.88, p<0.001) correlation with hs-CRP. Glycated hemoglobin and serum creatinine were linearly related with inflammatory marker. When creatinine increased by 1 unit, hs-CRP increased by 0.84 units (β=0.84, p=<0.001). Conclusion: This study concludes that the increase in serum hs-CRP value type 2 diabetic patients increase the risk of diabetic nephropathy and thus increase the value of serum creatinine level. Journal of Current and Advance Medical Research, July 2022;9(2):59-62

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三级医院2型糖尿病患者hsCRP与血清肌酐的关系

背景:高敏c反应蛋白(hs-CRP)是炎症的标志物。CRP可能在肾病和慢性肾脏疾病的炎症预测中发挥重要作用。目的:探讨2型糖尿病患者hs-CRP水平与血清肌酐水平的关系。方法:这是一项以医院为基础的分析、定量研究，研究对象为2型糖尿病患者，在孟加拉国达卡BIRDEM总医院生物化学系进行。分析患者血清hs-CRP、血清肌酐、血糖及家族史。结果:该观察性研究显示，更多的糖尿病患者血清肌酐水平较高(41% vs 59%)。67.6%的研究人群有中高水平的hsCRP。伴有肾损害的糖尿病患者hs-CRP明显升高(1.66±0.86比7.01±3.44,p<0.001)。血清肌酐与hs-CRP呈正相关(r=0.88, p<0.001)。糖化血红蛋白和血清肌酐与炎症标志物呈线性相关。肌酐每升高1单位，hs-CRP升高0.84单位(β=0.84, p=<0.001)。结论:本研究认为2型糖尿病患者血清hs-CRP值升高可增加糖尿病肾病的发生风险，从而使血清肌酐值升高。现代与先进医学研究，2022;9(2):59-62

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Journal of Current and Advance Medical Research

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