Mycoplasmosis: experimental pyelonephritis in rats; Demonstration of antibody in urine and serum.

Abstract

The concentration and persistence of M. arthritidis in obstructed and unobstructed kidneys of rats after intracardial inoculation has been investigated. Inoculation of 108 c.f.u. M. arthritidis, giving a deposit of 104 c.f.u./g kidney tissue, depressed the resistance against E. coli so that secondary intravenous inoculation of 106 or 107 of E. coli would be followed by severe acute pyelonephritis. These doses of E. coli could not provoke inflammation if given without primary mycoplasma inoculation.