Spontaneous closure of isolated Ventricular septal defect in the first year

Q4 Medicine
Jelica Predojević-Samardžić, Nina Maric, O. Ljuboja
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Abstract

Background/Aim: Ventricular septal defect (VSD) is the most common congenital heart anomaly that in many cases closes spontaneously. The spontaneous closure (SC) rate of VSD varies widely between studies. The aim of this study was to identify clinical and echocardiographic factors influencing SC of isolated VSD in the first year of life among a group of patients presented at the Paediatric Clinic. Methods: Prospective study was performed in 60 consecutive patients with trivial, small or medium isolated VSD during the first year of life. Patients were divided into groups, according to gender and gestational age of the patient, type, number and the size of the defect and persistence of pulmonary hypertension. The size of defect was described in comparison to the diameter of the aortic annulus (VSD/Ao ratio). Results: At the time of diagnosis, the mean VSD/Ao ratio was 0.33 mm. Muscular VSD was more common (76.7 %) than perimembranous (23.3 %). SC of VSD occurred in 60 % of all patients, in case of muscular defect in 73.9 % and in case of perimembranous in 14.3 %. There was a negative correlation between defect size and SC rate. SC probability for a given defect size was described by the formula: probability = -1.82933X+1.20145. None defect with pulmonary hypertension closed. Conclusion: It was found that type and size of VSD and the persistence of pulmonary hypertension were significant predictors for SC, while gender and gestational age of the patient and the number of defects were not. This study can be useful in predicting the natural outcome of the VSD to make proper follow-up and management plans.
孤立性室间隔缺损第一年的自发性关闭
背景/目的:室间隔缺损(Ventricular septal缺损,VSD)是最常见的先天性心脏异常,在许多情况下会自发闭合。在不同的研究中,VSD的自发闭合率差异很大。本研究的目的是确定在儿科诊所就诊的一组患者中,临床和超声心动图因素对孤立性室间隔sd第一年SC的影响。方法:前瞻性研究对60例1岁以内的轻度、小型或中度孤立性室间隔缺损患者进行了连续研究。根据患者的性别、胎龄、肺动脉高压的类型、数量和大小及持续时间进行分组。缺损的大小与主动脉环的直径比较(VSD/Ao比值)。结果:诊断时,平均VSD/Ao比值为0.33 mm。肌肉性室间隔缺损(76.7%)比膜周性室间隔缺损(23.3%)更为常见。60%的VSD患者发生SC, 73.9%的VSD患者发生肌肉缺损,14.3%的VSD患者发生膜周缺损。缺陷大小与SC率呈负相关。给定缺陷尺寸的SC概率由公式描述:概率= -1.82933X+1.20145。无肺动脉高压闭合缺损。结论:室间隔缺损的类型、大小和肺动脉高压的持续性是SC发生的重要预测因素,而性别、胎龄和缺陷数量对SC的发生无显著影响。本研究有助于预测室间隔缺损的自然结局,制定适当的随访和治疗计划。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.60
自引率
0.00%
发文量
13
审稿时长
4 weeks
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