Epidural morphine for postoperative analgesia after Caesarean section

Shymala Kumarasamy, Y.C. Choy
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引用次数: 4

Abstract

Introduction

This prospective randomized double-blind study compared the effectiveness and duration of analgesia of epidural morphine 4 mg and 5 mg for postoperative analgesia after Caesarean section.

Materials and methods

Sixty ASA I and II patients were randomized into 2 groups, Group A received epidural morphine 4 mg while Group B received epidural morphine 5 mg. All patients were provided with patient controlled analgesia (PCAM), for use as rescue analgesia. Pain was assessed using visual analogue score at 4, 8, 12, 16, 20 and 24 h. Time to first demand of patient controlled analgesia, cumulative morphine consumption and side effects were documented.

Results

The VAS for pain was significantly lower in Group B at 16, 20 and 24 h. The mean cumulative PCAM consumption was significantly lower in Group B. The incidence of nausea, vomiting (PONV) and pruritus was significantly higher in Group B, p < 0.05. There was no incidence of excessive sedation or respiratory depression.

Conclusion

Epidural morphine 5 mg provided adequate and longer duration of analgesia but resulted in higher frequency of pruritus and vomiting.

硬膜外吗啡用于剖宫产术后镇痛
本前瞻性随机双盲研究比较了硬膜外吗啡4mg和5mg用于剖宫产术后镇痛的有效性和持续时间。材料与方法60例ASAⅰ、ⅱ型患者随机分为2组,A组给予硬膜外吗啡4 mg, B组给予硬膜外吗啡5 mg。所有患者均给予患者自控镇痛(PCAM),作为抢救镇痛。在4、8、12、16、20和24小时用视觉模拟评分评估疼痛。记录患者首次自控镇痛所需时间、吗啡累积用量和副作用。结果B组患者疼痛VAS评分在16、20、24 h均明显低于对照组,PCAM平均累计消耗明显低于对照组,恶心、呕吐(PONV)、瘙痒发生率明显高于对照组,p <0.05. 没有发生过度镇静或呼吸抑制。结论硬膜外吗啡5mg镇痛效果充分,持续时间长,但瘙痒、呕吐发生率较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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