Value of ultrasound combined with serum CA125, CA199 and CEA in the differential diagnosis of ovarian benign and malignant tumors

Q4 Medicine

中国医师杂志 Pub Date : 2020-02-29 DOI:10.3760/CMA.J.ISSN.1008-1372.2020.02.020

Wan Zhou, Heng Zhang, Geping Zhang, Cuirong Bai

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引用次数: 0

Abstract

Objective To investigate the diagnostic values of ultrasonography combined with serum cancer antigen 125 (CA125), serum carbohydrate antigen 199 (CA199), serum carcinoembryonic antigen (CEA) in ovarian malignant tumors. Methods From November 2015 to December 2017, 140 patients with ovarian cancer admitted to the hospital were selected as subjects, and ultrasound examination was carried out with IU22 ultrasound diagnostic instrument. The patients were divided into 92 cases of benign ovarian tumors and 48 cases of malignant ovarian tumors through pathological diagnosis. The serum CA125, CA199 and CEA of all patients were detected by automatic biochemical analyzer, and receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of four combined detection in ovarian malignancies. Results The coincidence rate of ultrasound diagnosis in ovarian benign tumor patients was significantly higher than that in ovarian cancer patients (P<0.05). The levels of serum CA125, CA199 and CEA in benign ovarian tumors were significantly lower than those in malignant ovarian tumors (P<0.05), and the levels of serum CA125, CA199 and CEA in patients with stage Ⅰ to Ⅱ were significantly lower than those in stage Ⅲ to Ⅳ (P<0.05). The area of serum CA125, CA199 and CEA under the ROC curve was 0.788, 0.750 and 0.708, respectively. The boundary points of diagnosis were 50.61 U/ml, 36.47 U/ml and 4.32 ng/ml, respectively. The area under the combined diagnosis curve of the serum CA125, CA199 and CEA was 0.832. The sensitivity, specificity and accuracy of the combined detection were higher than that of single index detection and serum combined detection. Conclusions Ultrasound combined with serum CA125, CA199 and CEA levels detection can improve the sensitivity, specificity and accuracy of diagnosis of ovarian benign and malignant tumors, which has certain clinical value. Key words: Ultrasonography; CA125; CA199; Carcinoembryonic antigen; Ovarian neoplasms

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超声联合血清CA125、CA199、CEA在卵巢良恶性肿瘤鉴别诊断中的价值

目的探讨超声检查联合血清癌抗原125 (CA125)、血清碳水化合物抗原199 (CA199)、血清癌胚抗原(CEA)对卵巢恶性肿瘤的诊断价值。方法选取2015年11月至2017年12月我院收治的140例卵巢癌患者为研究对象，采用IU22超声诊断仪进行超声检查。经病理诊断分为卵巢良性肿瘤92例，卵巢恶性肿瘤48例。采用全自动生化分析仪检测所有患者血清CA125、CA199和CEA，并采用受试者工作特征(ROC)曲线分析四项联合检测对卵巢恶性肿瘤的诊断价值。结果卵巢良性肿瘤患者超声诊断符合率明显高于卵巢癌患者(P<0.05)。良性卵巢肿瘤患者血清CA125、CA199、CEA水平显著低于恶性卵巢肿瘤患者(P<0.05)，Ⅰ~Ⅱ期患者血清CA125、CA199、CEA水平显著低于Ⅲ~Ⅳ期患者(P<0.05)。血清CA125、CA199、CEA的ROC曲线下面积分别为0.788、0.750、0.708。诊断边界点分别为50.61 U/ml、36.47 U/ml和4.32 ng/ml。血清CA125、CA199、CEA联合诊断曲线下面积为0.832。联合检测的敏感性、特异性和准确性均高于单项指标检测和血清联合检测。结论超声联合血清CA125、CA199、CEA水平检测可提高卵巢良恶性肿瘤诊断的敏感性、特异性和准确性，具有一定的临床价值。关键词:超声检查;CA125;CA199;癌胚抗原;卵巢肿瘤

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来源期刊

中国医师杂志 Medicine-Medicine (all)

CiteScore

0.10

自引率

0.00%

发文量

20937

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