Case Series Evaluating Lymphocyte Subgroups at Diagnosis and After Treatment in Multisystem Inflammatory Syndrome Associated with COVID-19 in Children

Abstract

Lymphopenia, Increased B cell count, reversal of the CD4/CD8 ratio, and Increased active T cell count may be beneficial In the early diagnosis of MIS-C. Since It Is thought that the cytokine storm causes complications In MIS-C, Immediate administration of IVIG treatment Is considered essential. The disease was considered a new multisystem inflammatory syndrome, and with the increase in awareness, it has been reported more frequently in children (MIS-C) in Europe and the United States (2,3). Since the disease is thought to cause complications by leading to cytokine storms, immediate administration of intravenous immunoglobulin (IVIG) treatment is deemed important, and it is also essential to emphasize that IVIG treatment leads to marked cellular changes. Case 2 A nine-year-old male patient presented with fever, abdominal pain, headache, and diarrhea that had been present for five days, followed by a rash, conjunctivitis, and cervical lymphadenopathy. [...]the patient was considered to have atypical Kawasaki disease. According to a review, the most common signs and symptoms reported during MIS-C consisted of abdominal pain (61.9%), vomiting (61.8%), skin rash (55.3%), diarrhea (53.2%), hypotension (49.5%), and conjunctivitis (48.4%), and particularly gastrointestinal (90.9%), cardiovascular (86.5%), or dermatological or mucocutaneous (70.9%) involvement (2).