R. Miladi, M. Zamanian, A. Janbakhsh, F. Mansouri, B. Sayad, M. Afsharian, S. Vaziri, Zeinab Mohseni Afshar, M. Shirvani, Mitra Tarlan, S. Khazaei
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引用次数: 0
Abstract
Background: Nosocomial infections are important medical concerns in developed and developing countries. Pseudomonas aeruginosa is considered the third leading cause of nosocomial infections following Staphylococcus aureus and Escherichia coli. Objectives: The present study aimed to determine the antibiotic resistance of isolated P. aeruginosa strains in the patients admitted to Imam Reza Hospital in Kermanshah, Iran. Methods: This descriptive, cross-sectional study was conducted on 900 patients with positive P. aeruginosa cultures who were admitted to Imam Reza Hospital in Kermanshah, Iran during 2016-2018. Bacterial isolates were separated using laboratory tests, and the standard disc-diffusion method was used to assess antibiotic susceptibility based on the CLSI protocol. Data analysis was performed in SPSS version 24. Results: The majority of the P. aeruginosa-positive cases were isolated from the emergency ward (44.3%), intensive care unit (21.9%), blood samples (40.4%), and urine samples (18.7%). The highest antibiotic resistance was observed against cotrimoxazole, ceftriaxone, ampicillin, ampicillin-sulbactam, nitrofurantoin, nalidixic acid, cefazolin, and cefixime. In addition, ciprofloxacin and imipenem were the most effective antibiotics against P. aeruginosa with the sensitivity of 68.1% and 57.2%, respectively. Conclusions: According to the results, P. aeruginosa had high resistance against antibiotics such as cotrimoxazole and ceftriaxone. Therefore, these antibiotics should be used correctly and reasonably, and epidemiological studies in this regard should be focused on proposing national programs to prevent the further spread of antibiotic resistance.
背景:医院感染在发达国家和发展中国家都是重要的医疗问题。铜绿假单胞菌被认为是继金黄色葡萄球菌和大肠杆菌之后医院感染的第三大原因。目的:本研究旨在确定伊朗克尔曼沙阿伊玛目礼萨医院住院患者中分离的铜绿假单胞菌菌株的抗生素耐药性。方法:对2016-2018年在伊朗克尔曼沙阿伊玛目礼萨医院入院的900例铜绿假单胞菌培养阳性患者进行了描述性横断面研究。采用实验室分离法分离细菌,并根据CLSI方案采用标准圆盘扩散法评估抗生素敏感性。数据分析采用SPSS version 24进行。结果:铜绿假单胞菌阳性病例主要来自急诊病房(44.3%)、重症监护病房(21.9%)、血液(40.4%)和尿液(18.7%)。对复方新诺明、头孢曲松、氨苄西林、氨苄西林-舒巴坦、呋喃妥因、萘啶酸、头孢唑林和头孢克肟的耐药性最高。此外,环丙沙星和亚胺培南是对铜绿假单胞菌最有效的抗生素,敏感性分别为68.1%和57.2%。结论:铜绿假单胞菌对复方新诺明、头孢曲松等抗生素均有较高耐药性。因此,应正确合理地使用这些抗生素,并在这方面的流行病学研究应侧重于提出国家规划,以防止抗生素耐药性的进一步传播。