Adult-Onset Still's Disease: Persistent Pruritic Erythematous Plaques and Papules

Abstract

with features similar to the systemic form of juvenile idiopathic arthritis (sJIA) by Bywaters in 1971.1 It is a rare, acute-onset, systemic inflammatory disease with unknown etiology that is responsible for a significant proportion of cases of fever of unknown orgin. Its pathogenesis is unknown, infectious agents as initiators of the disease have implicated but a definitive agent has been revealed.2 Current opinion that increased cytokine production such as IL-1, IL-6, IL-18, TNF-α and IFNγ plays an important pathophysiological role in AOSD.3