Effects of selenium yeast combined with levothyroxine sodium on Hashimoto thyroiditis complicated by hypothyroidism

Z. Qu, Tingting Li, Hao-Jie Guan, Jing Huo, Yu Chen
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Abstract

Objective To investigate the therapeutic effects of selenium yeast combined with levothyroxine sodium on Hashimoto thyroiditis patients with hypothyroidism. Methods The clinical data from 85 patients with Hashimoto thyroiditis and hypothyroidism admitted to Dezhou People’s Hospital from February 2018 to March 2019 were retrospectively analyzed. According to the drug treatment plans, patients were divided into the control group (42 cases treated with levothyroxine sodium) and observation group (43 cases treated with selenium yeast and levothyroxine sodium). Both groups were treated continuously for 90 d, and the clinical effects of the two groups were observed. The changes of thyroid function index, thyroid peroxidase antibody and thyroglobulin antibody of the two groups before and after treatment were compared. And the adverse reactions of the two groups were recorded. Results The total effective rate of the observation group (93.02%, 40/43) was higher than that of the control group (76.19%, 32/42), P 0.05). Conclusions Selenium yeast combined with levothyroxine sodium can effectively improve thyroid function, reduce thyroid antibodies and effectively control the incidence of adverse reactions in Hashimoto thyroiditis patients with hypothyroidism. Key words: Hashimoto thyroiditis; Hypothyroidism; Selenium yeast; Levothyroxine sodium
酵母硒联合左旋甲状腺素钠治疗桥本甲状腺炎合并甲状腺功能减退的疗效观察
目的探讨酵母硒联合左旋甲状腺素钠治疗桥本甲状腺炎合并甲状腺功能减退的疗效。方法回顾性分析2018年2月至2019年3月德州市人民医院收治的85例桥本甲状腺炎合并甲状腺功能减退患者的临床资料。根据药物治疗方案将患者分为对照组(42例左甲状腺素钠治疗)和观察组(43例酵母硒+左甲状腺素钠治疗)。两组均连续治疗90 d,观察两组患者的临床疗效。比较两组患者治疗前后甲状腺功能指数、甲状腺过氧化物酶抗体、甲状腺球蛋白抗体的变化。并记录两组患者的不良反应。结果观察组总有效率(93.02%,40/43)高于对照组(76.19%,32/42),P < 0.05。结论酵母硒联合左旋甲状腺素钠可有效改善桥本甲状腺炎合并甲状腺功能减退患者的甲状腺功能,降低甲状腺抗体,有效控制不良反应的发生。关键词:桥本甲状腺炎;甲状腺功能减退;硒酵母;左旋甲状腺素钠
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