AERVA JAVANICA MEDIATED SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF ZINC OXIDE NANOPARTICLES

G. Afzal, A. Jamal, S. Kiran, G. Mustafa, F. Ahmad, S. Saeed, H. I. Ahmad, S. Dawood
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引用次数: 5

Abstract

Zinc is an indispensable trace element in the human body. Nano sized zinc-based particles have extensive applications in different fields such as medicine, agriculture and biotechnology. The present study was designed to describe the rapid, simple and environment friendly synthesis of zinc oxide nanoparticles (ZnO NPs) using Aerva javanica. In the current study, biosynthesis and characterization of ZnO NPs using Aerva javanica leaf extract is reported for the first time. Synthesized ZnO NPs were characterized by X-Ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) techniques. Synthesized ZnO NPs were tested against antimicrobial activity using the agar diffusion method. Antibacterial activity of ZnO NPs (10 mg/mL) was measured and zones of inhibition (MIC) against S. aureus and P. aeruginosa were measured as 13.5 mm + 0.8 and 5 + 2.8 mm while ZnO NPs (40 mg/mL) exhibited 18.4 + 4.3 and 8 + 2.8 mm for S. aureus and P. aeruginosa respectively. Antifungal activity of ZnO NPs (10 mg/mL) was measured and MIC against C. albicans and A. niger were recorded as 2.6 mm + 1.7 and 2+ 0.5 mm while ZnO NPs (40 mg/mL) exhibited 6.6 + 2.0 and 2.5 + 0.5 mm for C. albicans and A. niger respectively. Our study concluded that MIC for S. aureus and C. albicans was found to be higher as compared to P. aeruginosa and A. niger. Data analysis showed that ZnO NPs had a significant inhibitory antibacterial effect as compared to antifungal. Thus, present study depicts that the plant extract of A. javanica can be a valuable natural resource to synthesize the functional nanomaterials for targeted applications particularly in molecular medicine.
javanica Aerva介导氧化锌纳米颗粒的合成、表征及抗菌评价
锌是人体不可缺少的微量元素。纳米锌基粒子在医药、农业和生物技术等领域有着广泛的应用。本研究旨在描述一种快速、简单、环境友好的氧化锌纳米颗粒(ZnO NPs)的合成方法。本研究首次报道了利用水芹叶提取物生物合成氧化锌NPs并进行了表征。利用x射线衍射(XRD)和傅里叶变换红外光谱(FTIR)对合成的ZnO纳米粒子进行了表征。采用琼脂扩散法对合成的ZnO NPs进行抑菌活性测试。ZnO NPs (10 mg/mL)对金黄色葡萄球菌和铜绿假单胞菌的抑菌活性分别为13.5 mm + 0.8和5 + 2.8 mm, ZnO NPs (40 mg/mL)对金黄色葡萄球菌和铜绿假单胞菌的抑菌区分别为18.4 + 4.3和8 + 2.8 mm。测定了氧化锌NPs (10 mg/mL)对白色念珠菌和黑孢杆菌的抑菌活性,测得氧化锌NPs (40 mg/mL)对白色念珠菌和黑孢杆菌的MIC分别为2.6 mm + 1.7和2+ 0.5 mm,氧化锌NPs (40 mg/mL)对白色念珠菌和黑孢杆菌的MIC分别为6.6 + 2.0和2.5 + 0.5 mm。我们的研究得出结论,金黄色葡萄球菌和白色念珠菌的MIC高于铜绿假单胞菌和黑单胞菌。数据分析表明,ZnO NPs具有明显的抑菌作用。因此,本研究表明,爪哇提取物是一种有价值的天然资源,可用于合成具有针对性的功能纳米材料,特别是在分子医学领域。
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