Glomerular basement membrane damage and leaking of structural proteins in among different stages of type 2 diabetes mellitus patients

IF 0.6 Q3 Medicine

Indian Journal of Otolaryngology and Head and Neck Surgery Pub Date : 2021-10-15 DOI:10.18231/j.ijashnb.2021.019

Shantharam V, R. K

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引用次数: 0

Abstract

Type 2 Diabetes mellitus (T2DM) is a syndrome of disorders characterized by hyperglycemia caused due to a relative or absolute deficiency of insulin, decreased glucose utilization. The metabolic derangements in diabetes lead to secondary complications that affect multiple organ systems particularly on kidney. For early detection of kidney damage in T2DM patients are important by using certain type of urinary proteins. We aimed to evaluate the glomerular basement membrane damage and leaking of structural proteins in among different stages of type 2 diabetes mellitus patients. A total 150 type 2 diabetes mellitus patients were included in the present study and again sub classified into 2 types (Normoalbuminuria 50, Microalbuminuria 50) based on their urinary ACR and also included 50 age, gender matched healthy controls. The FBS, PPBS, Urea, Creatinine, HbA1C, Urinary Albumin was analysed by using laboratory standard methods and Urinary Adiponectin was measured by using were collected from the all subjects. A statistical was performed by using SPSS Version 21.0 and P value considers < 0.05 is statistically significant. The significantly elevated levels of plasma FBS, PPBS, Serum Urea, Creatinine, HbA1c, Urinary albuminuria and Urinary Adiponectin observed in two groups of type 2 diabetes mellitus when compared to healthy controls. The Urinary Adiponectin was positively correlated with blood sugar levels and urinary albumin in two groups of diabetes mellitus. The data showed a significantly damaged foot process of podocytes and glomerular basement membrane leads to leaking of certain urinary proteins.The elevated levels of Urinary Proteins and HbA1c, Urinary Albuminuria directly indicate the damage of podocytes and glomerular basement membrane in the kidney. These studies suggest continuous monitoring of these parameters may helpful for progression of type 2 diabetes mellitus complications.

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2型糖尿病不同分期肾小球基底膜损伤及结构蛋白渗漏的研究

2型糖尿病(T2DM)是一种以高血糖为特征的疾病综合征，由于胰岛素的相对或绝对缺乏，葡萄糖利用率降低而引起。糖尿病的代谢紊乱可导致继发性并发症，影响多器官系统，尤其是肾脏。使用特定类型的尿蛋白对早期发现T2DM患者肾损害具有重要意义。目的探讨2型糖尿病不同分期患者肾小球基底膜损伤及结构蛋白渗漏情况。本研究共纳入150例2型糖尿病患者，根据尿ACR将其再次分为正常蛋白尿50型和微量蛋白尿50型，并纳入50例年龄、性别匹配的健康对照。采集所有受试者的FBS、PPBS、尿素、肌酐、HbA1C、尿白蛋白采用实验室标准方法分析，尿脂联素采用实验室标准方法测定。采用SPSS Version 21.0进行统计，P值认为< 0.05有统计学意义。两组2型糖尿病患者血浆FBS、PPBS、血清尿素、肌酐、HbA1c、尿白蛋白尿和尿脂联素水平均显著高于健康对照组。两组糖尿病患者尿脂联素水平与血糖、尿白蛋白水平呈正相关。数据显示足细胞足突和肾小球基底膜明显受损，导致某些尿蛋白渗漏。尿蛋白、HbA1c、尿白蛋白水平升高直接提示足细胞和肾小球基底膜的损伤。这些研究表明，持续监测这些参数可能有助于2型糖尿病并发症的进展。

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来源期刊

Indian Journal of Otolaryngology and Head and Neck Surgery Medicine-Otorhinolaryngology

CiteScore

0.90

自引率

0.00%

发文量

226

审稿时长

3 months

期刊介绍： Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress. IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc. The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world. The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members. Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.