Enterococcus and COVID-19: The Emergence of a Perfect Storm?

Journal of International Translational Medicine Pub Date : 2022-06-07 DOI:10.3390/ijtm2020020

Dan-Alexandru Toc, Răzvan-Marian Mihăilă, A. Botan, Carina Nicoleta Bobohalma, Giulia Andreea Risteiu, Bogdan Nicolae Simut-Cacuci, Bianca Steorobelea, Stefan Troanca, L. Junie

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引用次数: 7

Abstract

(1) Background: Based on the uncontrolled use of antibiotics and the lack of worldwide-accepted healthcare policies, the COVID-19 pandemic has provided the best premises for the emergence of life-threatening infections. Based on changes described in the intestinal microbiome, showing an increased number of Enterococcus bacteria and increased intestinal permeability due to viral infection, infections with Enterococcus have taken the spotlight in the healthcare setting; (2) Methods: We conducted a brief review in order to analyze the relationship between the two pathogens: the SARS-CoV-2 virus and the Enterococcus bacterial genus. We searched in PubMed, the Cochrane Library electronic database and MedNar and included twenty-one studies based on relevance; (3) Results: The existing studies show a statistically significant difference in the composition of the intestinal microbiome, favoring Enterococcus genus, when compared to a control group. Changes also seem to persist over a period of time, suggesting possible implications for long COVID. Regarding bloodstream infections, Enterococcus is statistically significantly isolated more often when compared to the pre-COVID-19 era, and to a control group of non-COVID-19 patients. (4) Conclusions: The intimate synergy between COVID-19 and Enterococcus has the potential to pose a real threat to human healthcare, and more extensive research is needed to explore the relationship between these two pathogens.

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肠球菌和COVID-19:一场完美风暴的出现?

(1)背景:基于抗生素使用不受控制和缺乏全球公认的医疗保健政策，COVID-19大流行为危及生命的感染的出现提供了最佳前提。肠道微生物组的变化表明，由于病毒感染，肠球菌细菌数量增加，肠道通透性增加，肠球菌感染已成为医疗保健机构关注的焦点;(2)方法:对SARS-CoV-2病毒和肠球菌属两种病原体的关系进行简要综述。我们检索了PubMed、Cochrane图书馆电子数据库和MedNar，根据相关性纳入了21项研究;(3)结果:现有研究表明，与对照组相比，肠道微生物组的组成有统计学意义上的差异，肠球菌属更占优势。变化似乎也会持续一段时间，这表明可能对COVID产生长期影响。在血液感染方面，与covid -19前和非covid -19对照组相比，肠球菌的分离率在统计学上显著提高。(4)结论:COVID-19与肠球菌之间的密切协同作用有可能对人类健康构成真正的威胁，需要更广泛的研究来探索这两种病原体之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of International Translational Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

自引率

0.00%

发文量

317

审稿时长

8 weeks

期刊介绍： Journal of International Translational Medicine (JITM, ISSN 2227-6394), founded in 2012, is an English academic journal published by Journal of International Translational Medicine Co., Ltd and sponsored by International Fderation of Translational Medicine. JITM is an open access journal freely serving to submit, review, publish, read and download full text and quote. JITM is a quarterly publication with the first issue published in March, 2013, and all articles published in English are compiled and edited by professional graphic designers according to the international compiling and editing standard. All members of the JITM Editorial Board are the famous international specialists in the field of translational medicine who come from twenty different countries and areas such as USA, Britain, France, Germany and so on.