Orthostatic-induced Hypotension Attenuates Cold Pressor Pain Perception

Q4 Medicine
K. Wonders, D. Drury
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引用次数: 1

Abstract

In recent years, numerous studies have established a connection between blood pressure and nocioception. While this connection is well documented in the literature, its underlying physiological mechanisms have yet to be elucidated. Much attention has focused on the relationship between cardiovascular regulatory centers and nocioception, yet the intricacies of this relationship have not been fully explored. Therefore, the purpose of this investigation was to examine the role of the baroreflex system as a modulator of pain perception. Twenty normotensive males participated in two laboratory sessions. Time to cold pain threshold and pain tolerance was measured at rest during the first visit. On visit two, blood pressure was orthostatically manipulated via tilt table at postures 90o, 120o, and 180o. Orthostatic manipulation significantly lowered systolic blood pressure (SBP), pain threshold, and pain tolerance from seated baseline at 120o and 180o. The regression models for baroreceptor reflex sensitivity (BRS) assessed during seated baseline and at 120o and 180o revealed a significant negative beta weight for the effect of SBP. A significant negative beta weight for the effects of BRS, SBP, and their interaction was observed at 90o. In conclusion, orthostatic baroreceptor activation appears to exert an inhibitory effect on the brain that decreases pain sensitivity. This article is available at The Cupola: Scholarship at Gettysburg College: http://cupola.gettysburg.edu/healthfac/32 Orthostatic Hypotension and Pain Perception 21 Journal of Exercise Physiologyonline (JEPonline) Volume 13 Number 1 February 2010 Managing Editor Tommy Boone, PhD, MPH Editor-in-Chief Jon K. Linderman, PhD Review Board Todd Astorino, PhD Julien Baker, PhD Tommy Boone, PhD Eric Goulet, PhD Robert Gotshall, PhD Alexander Hutchison, PhD M. Knight-Maloney, PhD Len Kravitz, PhD James Laskin, PhD Derek Marks, PhD Cristine Mermier, PhD Chantal Vella, PhD Ben Zhou, PhD Official Research Journal of the American Society of Exercise Physiologists (ASEP) ISSN 1097-975 Systems Physiology Cardiopulmonary Orthostatic-induced Hypotension Attenuates Cold Pressor Pain Perception KAREN WONDERS and DANIEL DRURY Wright State University, Department of Health, Physical Education and Recreation, Dayton, OH 45435 USA, Gettysburg College, Department of Health Sciences, Gettysburg, PA, USA
直立性低血压可减弱冷压疼痛感知
近年来,许多研究已经建立了血压和痛觉之间的联系。虽然这种联系在文献中有很好的记载,但其潜在的生理机制尚未阐明。许多注意力都集中在心血管调节中心和痛觉之间的关系上,但这种关系的复杂性尚未得到充分探讨。因此,本研究的目的是研究压力反射系统作为疼痛感知调节剂的作用。20名血压正常的男性参加了两次实验。在第一次访问时,在休息时测量到冷痛阈和疼痛耐受性的时间。在第二次访问中,通过倾斜台以90o、120o和180o的姿势直立控制血压。直立操作显著降低收缩压(SBP),疼痛阈值和疼痛耐受性从坐姿基线在1200度和180度。在坐姿基线和120度和180度时评估的压力感受器反射敏感性(BRS)回归模型显示,收缩压的影响具有显著的负β权重。在90度时观察到BRS、SBP及其相互作用的显著负β权值。综上所述,直立压力感受器的激活似乎对大脑产生抑制作用,从而降低疼痛敏感性。这篇文章可以在The Cupola上找到:葛底斯堡学院奖学金:http://cupola.gettysburg.edu/healthfac/32体位性低血压和痛感21运动生理学杂志在线(JEPonline)第13卷第1期2010年2月总编辑汤米·布恩博士,公共卫生硕士主编乔恩·k·林德曼,博士审查委员会托德·阿斯托里诺博士,朱利安·贝克博士,汤米·布恩博士,埃里克·古莱特博士,罗伯特·戈特希尔博士,亚历山大·哈奇森博士,M. Knight-Maloney博士,Len Kravitz博士,James Laskin博士,Derek Marks博士,克里斯汀·默米尔博士,Chantal Vella博士,Ben Zhou博士,美国运动生理学学会(ASEP)官方研究期刊,ISSN 1097-975系统生理学心肺正立诱发的低血压减轻冷压疼痛感知KAREN WONDERS和DANIEL DRURY Wright州立大学,健康,体育和娱乐系,代顿,OH 45435 USA, Gettysburg学院,健康科学系,Gettysburg, PA, USA
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Exercise Physiology Online
Journal of Exercise Physiology Online Medicine-Physiology (medical)
CiteScore
0.70
自引率
0.00%
发文量
0
期刊介绍: The Journal of Exercise Physiologyonline, published by the American Society of Exercise Physiologists, is a professional peer reviewed Internet-based journal devoted to original research in exercise physiology. The journal is directed by the Editor-In-Chief with supporting editorial assistance via Associate Editors knowledgeable in the field of exercise physiology. JEPonline is the first electronic peer reviewed exercise physiology journal in the history of the profession.
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