Synthesis, Characterization and Study of Anti-Bacterial Activity of Some New Bis-Heterocyclic Derivatives

Abstract

through the reaction of an aromatic ketone with different aldehydes. The second step involves the reaction of chalcones derivatives ( D1-D3 ) with compound (B) in the presence of copper (I) to obtain a 1,2,3-triazoline compound ( H5 – H7 ). Different spectroscopy methods, such as FT-IR, 1 H-NMR, and 13 C-NMR, were used to identify synthesized compounds. The potential antibacterial activity of the synthesized heterocyclic derivatives has been finally tested as a third stage, using two types of bacteria ( Staphylococcus aureus and Escherichia coli ).