Challenges and pitfalls in diagnosis of Parosteal Osteosarcoma: A clinicopathologic study of 23 cases

M. Tariq, N. Din, Arsalan Ahmed, S. Pervez, Romana Idrees, S. Fatima, M. Umer, N. Kayani
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引用次数: 4

Abstract

Objective: Parosteal Osteosarcoma (PO) is an uncommon variant of osteosarcoma. Diagnosing PO is important due to itsmalignant nature but the diversity of histologic features makes it challenging by adding a number of soft tissue, bony andcartilaginous lesions into the list of differential diagnosis. Our aim was to study the clinicopathologic and histological features ofPO with emphasis on features helpful in its discrimination from other mimicking lesions. Methods: We reviewed 23 cases of PO diagnosed in our institution between January 2001 and August 2015. Results: Femur was the most commonly involved bone (68.2%) along with other long bones and rib in a single case. Soft tissuecomponent was graded as Grade1 in 9(39%), Grade2 in 8(34.7%) and Grade3 in 4(17.3%) cases. Bony component was seeneither in combination of or exclusively as parallel streams and interconnected trabeculae (mosaic-pattern). Out of 9 cases withcartilage component, 3 showed a cartilage cap. 2(8.6%) cases showed dedifferentiation into osteosarcoma. Conclusion: PO should always be considered in the differential diagnosis of every lesion arising from the bone surface.Knowledge of the variations in histologic features helps to reach the correct diagnosis which should never be made withoutradiological correlation.
骨旁骨肉瘤23例临床病理分析
目的:骨旁骨肉瘤(PO)是一种罕见的骨肉瘤。由于其微小的性质,诊断PO很重要,但组织学特征的多样性使其具有挑战性,因为在鉴别诊断列表中添加了许多软组织,骨和软骨病变。我们的目的是研究po的临床病理和组织学特征,重点是有助于区分其他模拟病变的特征。方法:回顾2001年1月至2015年8月在我院诊断的23例PO病例。结果:股骨及其他长骨、肋骨受累最多(68.2%)。软组织成分分级为1级9例(39%),2级8例(34.7%),3级4例(17.3%)。骨成分被认为是平行流和相互连接的小梁的组合或单独的(马赛克图案)。9例有软骨成分的病例中,3例出现软骨帽,2例(8.6%)出现脱分化为骨肉瘤。结论:骨表面病变的鉴别诊断应考虑PO。组织学特征的变化的知识有助于达到正确的诊断,这是不应该没有传统的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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