Clinical efficacy and metabolomic analysis of ozone major autohemotherapy for the treatment of herpes zoster.

Jing Yang, Kai Luo, Zhi-Ji Chen, Gua-Hui Zhang, Xin Yao, Shu-Xiu Feng, Ze-Lin Weng
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Abstract

Introduction: It is essential to understand the underlying changes in the patients' metabolic profiles that may be indicative of the therapy's effectiveness.

Aim: To prospectively analyse the clinical efficacy of ozone autohemotherapy in the treatment of acute herpes zoster and investigate its impact on serum metabolomics.

Material and methods: A total of 76 patients with acute herpes zoster between May 2018 and June 2020 were enrolled and divided into an experimental group and a control group. The pain location, Numeric Rating Scale (NRS) scores before and after treatment (1 week, 1 month, 3 months, and 6 months post-treatment), medication usage, and Quality of Sleep (QS) scores were prospectively analysed. Additionally, serum metabolomic data were obtained and analysed before and 6 months after the treatment.

Results: There were statistically significant differences in the total NRS scores before and after ozone autohemotherapy (p < 0.05). The NRS scores of both groups significantly decreased (p < 0.05). At the 6-month follow-up, no patients were lost, and 83 patients completed the follow-up. The NRS improvement at 1 week, 1 month, 3 months, and 6 months post-treatment in the experimental group was significantly lower than that in the control group (p < 0.05). There was no significant difference in the medication usage (pregabalin or tramadol sustained-release tablets) between the two groups (p > 0.05). One month after treatment, the QS score improvement in the diabetes group was significantly lower than that in the non-diabetes group (p < 0.05). Serum metabolomics analysis revealed three significantly decreased metabolites, namely creatine, adipate, and glucose, after treatment.

Conclusions: Ozone autohemotherapy is an effective treatment for acute herpes zoster patients and can rapidly and effectively alleviate pain symptoms in the short term. The changes in serum metabolomics may provide further insights into the treatment mechanism.

臭氧自体血液疗法治疗带状疱疹的临床疗效及代谢组学分析。
引言:了解可能指示治疗有效性的患者代谢谱的潜在变化是至关重要的。目的:前瞻性分析臭氧自体血液疗法治疗急性带状疱疹的临床疗效,探讨其对血清代谢组学的影响。材料与方法:选取2018年5月~ 2020年6月急性带状疱疹患者76例,分为实验组和对照组。前瞻性分析治疗前后(治疗后1周、1个月、3个月和6个月)疼痛部位、数值评定量表(NRS)评分、药物使用情况和睡眠质量(QS)评分。此外,在治疗前和治疗后6个月获得并分析血清代谢组学数据。结果:臭氧自血治疗前后NRS总分比较,差异有统计学意义(p < 0.05)。两组患者NRS评分均显著降低(p < 0.05)。随访6个月,无患者丢失,83例患者完成随访。实验组在治疗后1周、1个月、3个月、6个月的NRS改善程度均显著低于对照组(p < 0.05)。两组患者用药(普瑞巴林、曲马多缓释片)差异无统计学意义(p > 0.05)。治疗1个月后,糖尿病组QS评分改善程度显著低于非糖尿病组(p < 0.05)。血清代谢组学分析显示,治疗后三种代谢物显著降低,即肌酸、己二酸和葡萄糖。结论:臭氧自体血液疗法是治疗急性带状疱疹患者的有效方法,可在短期内迅速有效地缓解疼痛症状。血清代谢组学的变化可能为治疗机制提供进一步的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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