Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury

Shi-Ying Cai, J. Boyer
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引用次数: 11

Abstract

The mechanism of bile acid induced cholestatic liver injury remains controversial, thus hindering the development of new therapies for these diseases. In this research highlight, we briefly review the evolution of our understanding of the pathogenesis of bile acid induced liver injury, and summarize our recent findings on this topic. Our data suggests that under pathophysiological conditions bile acid induced liver injury is mediated by inflammatory responses that are initiated from stressed hepatocytes. We conclude by mentioning potential new therapeutic approaches for treating cholestatic liver injury based on these pathophysiologic concepts.
胆汁淤积性肝损伤中胆汁酸引发肝脏炎症机制的研究
胆汁酸诱导胆汁淤积性肝损伤的机制仍然存在争议,从而阻碍了这些疾病的新疗法的发展。在本研究重点中,我们简要回顾了我们对胆汁酸诱导肝损伤发病机制的认识演变,并总结了我们在这一主题上的最新发现。我们的数据表明,在病理生理条件下,胆汁酸诱导的肝损伤是由应激肝细胞引发的炎症反应介导的。最后,我们提出了基于这些病理生理学概念的治疗胆汁淤积性肝损伤的潜在新治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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