Solubility Prediction of Etodolac, Lamotrigine, Diazepam and Clonazepamin in Cosolvent Mixtures Using UNIQUAC Model

Abstract

Etodolac, Lamotrigine, diazepam, and clonazepamine are four important drugs in the pharmaceutical industry that optimizing the solvent concentration in the least amount can reduce the cost and toxicity of these drugs. Due to the lack of thermodynamic modeling based on the activity coefficient equation in previous studies for solubility of Etodolac, Lamotrigine, diazepam, and clonazepamine in aqueous solution, in this study, based on thermodynamic equations and UNIQUAC model, their solubility is optimized with the presence of water and ethanol. Based on the objective function defined, the error rate of the model optimization value was acceptable for each system. The results of this study can be used to better understand the intermolecular reaction of Etodolac, Lamotrigine diazepam, and clonazepamine in the presence of ethanol and water solvents. Also, the importance of the optimization results of this study in order to design a computer program to predict the solubility of these drugs is significant.