Is non-P450 enzyme inducing antiepileptic drugs the best ADEs choice for glioblastoma patients?

Abstract

The seizure prognosis of using P450 enzyme inducing and non-enzyme inducing antiepileptic drugs for seizure prophylaxis after glioma resection surgery has been investigated in several clinical studies. However, the results of these studies are inconsistent.  Additional multicenter RCTs are necessary to provide class I evidence on the role of AEDs in the treatment of glioma associated seizure.