Update on Rapid Diagnostics for COVID-19: A Systematic Review

Journal of International Translational Medicine Pub Date : 2022-06-17 DOI:10.3390/ijtm2020023

Bruna de Paula Dias, R. Gonçalves, Cyntia Silva Ferreira, Camila C. Barbosa, O. Arrieta, Samara Mayra Soares Alves dos Santos, Wellington Carvalho Malta, Mariela Alves e Silva, Maria Laura Maximiano Dias Gomes, A. Guimarães, L. Borges, Breno de Mello Silva

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引用次数: 1

Abstract

An accurate and rapid diagnosis of COVID-19 is an effective strategy for pandemic control, allowing disease screening and timely therapeutic intervention. We analyzed scientific reports about rapid tests for the diagnosis of COVID-19 to assess their reliability parameters. Medical Subject Headings terms or keywords related to point-of-care and rapid diagnostic testing for SARS-CoV-2 and COVID-19 were searched in data published from November 2020 to November 2021 in PubMed and Google Scholar databases. Notable differences were observed in sensitivity among direct tests that used different samples, and good accuracy was reported in a significant number of studies (>80%). Pediatric samples and samples with high Ct values (RT-PCR) had suboptimal sensitivity (range 45.4% to 66%). Further, a lack of sensitivity (<46.2%) was observed in point-of-care tests and in rapid diagnostic tests for antibody detection in the first days after infection, with increasing values in postinfection analysis (>60%). For serological detection of IgM or Antigen rapid diagnostic tests, no cross-reactivity was found with other coronaviruses. Therefore, although these tests are very important in facing the pandemic, they still need to be improved to test cross-reactivity against other pathogens, especially against other coronaviruses.

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2019冠状病毒病快速诊断最新进展:系统回顾

准确和快速诊断COVID-19是控制大流行的有效战略，可以进行疾病筛查和及时的治疗干预。对新冠肺炎快速诊断检测相关科学报告进行分析，评估其可靠性参数。在PubMed和Google Scholar数据库中检索2020年11月至2021年11月发布的数据，检索与SARS-CoV-2和COVID-19的即时护理和快速诊断检测相关的医学主题标题术语或关键词。在使用不同样本的直接试验中，观察到敏感性的显著差异，并且在大量研究中报告了良好的准确性(>80%)。儿童样本和高Ct值样本(RT-PCR)的敏感性不理想(范围为45.4%至66%)。此外，缺乏敏感性(60%)。在IgM血清学检测或抗原快速诊断试验中，未发现与其他冠状病毒交叉反应。因此，尽管这些检测在应对大流行方面非常重要，但仍需要改进，以检测与其他病原体，特别是与其他冠状病毒的交叉反应性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of International Translational Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

自引率

0.00%

发文量

317

审稿时长

8 weeks

期刊介绍： Journal of International Translational Medicine (JITM, ISSN 2227-6394), founded in 2012, is an English academic journal published by Journal of International Translational Medicine Co., Ltd and sponsored by International Fderation of Translational Medicine. JITM is an open access journal freely serving to submit, review, publish, read and download full text and quote. JITM is a quarterly publication with the first issue published in March, 2013, and all articles published in English are compiled and edited by professional graphic designers according to the international compiling and editing standard. All members of the JITM Editorial Board are the famous international specialists in the field of translational medicine who come from twenty different countries and areas such as USA, Britain, France, Germany and so on.