Lactoferrin of oral fluid is normal and in Alzheimer's disease: laboratory and diagnostic aspects (review of literature).

Q4 Health Professions
V. Bazarnyi, A. Sidenkova, D. Sosnin
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引用次数: 1

Abstract

The article discusses the clinical value of determining the lactoferrin protein in oral fluid - one of the representatives of the saliva proteome. The review is based on the analysis of modern literature, including systematic reviews, the results of multicenter prospective studies, review and original articles by leading experts in this field, presented in the databases PubMed, Scopus, CyberLeninka. The problems of the preanalytical stage, methods for determining lactoferrin are highlighted and information about its content in mixed saliva according to various authors is provided. Special attention is paid to the clinical and diagnostic value of the level of salivary lactoferrin in Alzheimer's disease. According to most authors, the diagnostic sensitivity of this parameter ranges from 87 to 100%. Some mechanisms of the relationship between this protein and the central nervous system (CNS) are shown. In conclusion, it is concluded that salivary lactoferrin can be an "indicator" of the formation of amyloid plaques and can be considered as one of the reliable biomarkers of Alzheimer's disease. This opinion is based both on fundamental ideas about the global relationship between innate immunity and the central nervous system, and on clinical data. The special advantage of this laboratory test is its non-invasiveness, which makes it more preferable in comparison with the determination of amyloid and tau proteins in the cerebrospinal fluid and blood.
口腔液乳铁蛋白是正常的,在阿尔茨海默病:实验室和诊断方面(文献回顾)。
本文讨论了唾液蛋白质组学的代表之一——口腔液中乳铁蛋白测定的临床价值。本综述基于对现代文献的分析,包括系统综述、多中心前瞻性研究的结果、该领域领先专家的综述和原创文章,并在PubMed、Scopus、CyberLeninka等数据库中发表。重点介绍了分析前阶段存在的问题、测定乳铁蛋白的方法以及不同作者对混合唾液中乳铁蛋白含量的介绍。特别关注唾液乳铁蛋白水平在阿尔茨海默病中的临床和诊断价值。大多数作者认为,该参数的诊断灵敏度在87 - 100%之间。揭示了该蛋白与中枢神经系统(CNS)关系的一些机制。综上所述,唾液乳铁蛋白可作为淀粉样斑块形成的“指示剂”,可作为阿尔茨海默病可靠的生物标志物之一。这一观点既基于先天免疫和中枢神经系统之间整体关系的基本观点,也基于临床数据。这种实验室检测的特殊优点是它的非侵入性,这使得它比测定脑脊液和血液中的淀粉样蛋白和tau蛋白更可取。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Klinichescheskaya Laboratornaya Diagnostika
Klinichescheskaya Laboratornaya Diagnostika Health Professions-Medical Laboratory Technology
CiteScore
0.90
自引率
0.00%
发文量
110
期刊介绍: The journal deals with theoretical and practical problems of clinical laboratory diagnosis, publishes editorial articles, reviews of literature, original articles, short reports, discussions, book reviews, current events, materials which may assist the practitioners, methods of laboratory investigations used in medicine, materials on the results of practical application of new methods of investigation in the following fields of clinical laboratory diagnosis: hematology, cytology, coagulation, biochemistry, immunology.
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