Pharmacokinetics of Basiliximab for the Prevention of Graft‐versus‐Host Disease in Patients Undergoing Hematopoietic Cell Transplantation with Minimal‐Intensity Cyclophosphamide and Fludarabine

J. Podichetty, B. Brinda, R. Nelson, Alissa H. Karr, N. Prasad, S. Quinney, Susanna Foxworthy Scott, P. Kiel
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引用次数: 2

Abstract

Basiliximab is an immunosuppressive monoclonal antibody used for rejection prevention following solid organ transplantation; the pharmacokinetics (PK) of basiliximab in this setting are known. Basiliximab may also be used for prophylaxis and treatment of graft‐versus‐host disease (GVHD) in patients undergoing allogeneic hematopoietic cell transplantation (HCT); however, the PK of basiliximab in this setting are not known. Clinical transplant providers expect variation in the volume of distribution and clearance after nonmyeloablative allogeneic transplantation (NMAT) compared with solid organ transplantation. Blood loss, organ site–specific antibody accumulation, and differences in blood product use during the two transplantation approaches may generate differences in basiliximab PK. Therefore, the objective of this study was to describe the PK of basiliximab after its addition to a minimally intense NMAT regimen, in conjunction with cyclosporine, for GVHD prophylaxis in patients with hematologic malignancies.
巴利昔单抗预防低剂量环磷酰胺和氟达拉滨造血细胞移植患者移植物抗宿主病的药代动力学研究
Basiliximab是一种免疫抑制单克隆抗体,用于预防实体器官移植后的排斥反应;巴昔单抗在这种情况下的药代动力学(PK)是已知的。Basiliximab也可用于预防和治疗同种异体造血细胞移植(HCT)患者的移植物抗宿主病(GVHD);然而,巴昔单抗在这种情况下的PK是未知的。临床移植提供者期望与实体器官移植相比,非清髓异体移植(NMAT)后的分布体积和清除率有所不同。在两种移植方法中,失血、器官特异性抗体积累和血液制品使用的差异可能会导致巴昔昔单抗PK的差异。因此,本研究的目的是描述巴昔昔单抗在最小强度NMAT方案中加入巴昔昔单抗并联合环孢素预防血液恶性肿瘤患者的GVHD后的PK。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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