Bioinformatic Prediction of Interaction between Flavonoids of Propolis of Honey Bee and Envelope Glycoprotein GP120

Abstract

Acquired immune deficiency syndrome (AIDS) is a kind of disease related to immune system caused by HIV virus. Up to now many medicinal compositions have been using for treatment of this disease both in In vivo and In vitro conditions. Caffeic Acid Phenethyl Ester (CAPE) is one of the most important compositions in honey bee propolis. The composition possesses anti-bacterial, anti-viral, anti-fungal, anti-oxidant, anti-inflammatory and anti-cancer properties. In this study we tried to predict bioinformatic interaction between CAPE and GP120. Molegro virtual docker (MVD) is used. The results obtained from docking showed us that the best pose which is derived from MolDock score for GP120 was -89.9759 with reranking score equal to -61. 1094. Bioinformatic studies show that Caffeic Acid Phenethyl Ester has interaction with Envelope glycoprotein GP120.