Impact of the growth hormone and IGF-1 on graft function and immune response in pediatric liver recipients

R. Kurabekova, O. Tsirulnikova, S. Y. Oleshkevich, I. Pashkova, G. Olefirenko
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Abstract

Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are the most important regulators of growth, regeneration and metabolism. The influence of GH and IGF-1 on pediatric liver transplant outcomes is mediated through growth and body weight regulation, specific effects on hepatocyte function and immune system activity. In recent years, the blood levels of these factors and life expectancy, both in healthy individuals and liver recipients, have been shown to be correlated. In pediatric liver recipients, neurohumoral regulation of graft function and other functions of the growing organism, has not been studied enough. The results of studies on the levels and dynamics of GH and IGF-1 in the blood of liver recipients can serve as a basis for assessing the state of graft using new minimally invasive methods and identifying therapeutic targets for personalized therapy. This review summarizes the current understanding of the significance of GH/IGF-1 hormones in hepatobiliary diseases and pediatric liver transplantation (LTx).
生长激素和IGF-1对儿童肝脏受者移植物功能和免疫反应的影响
生长激素(GH)和胰岛素样生长因子1 (IGF-1)是最重要的生长、再生和代谢调节因子。生长激素和IGF-1对儿童肝移植预后的影响是通过生长和体重调节、对肝细胞功能和免疫系统活性的特异性影响介导的。近年来,在健康个体和接受肝脏移植的个体中,这些因子的血液水平和预期寿命已被证明是相关的。在儿童肝脏受者中,移植物功能和生长有机体其他功能的神经体液调节尚未得到足够的研究。通过对肝受体血液中GH和IGF-1水平和动态的研究结果,可以作为利用新的微创方法评估移植物状态和确定个体化治疗靶点的基础。本文综述了GH/IGF-1激素在肝胆疾病和小儿肝移植(LTx)中的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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