Evaluation of the Structural disorder of the protein FMR1 with Carbon Composition

Baby Jerald, Gopalakrishnan Nair, E. Rajasekaran
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引用次数: 1

Abstract

Ever since the disorder of proteins is the main cause for many diseases. As compared with other disorders, the major reason that causes disease is of structural inability of many proteins. The potentially imminent availability of recent datasets helps one to discover the protein disorders, however in majority of cases, the stability of proteins depend on the carbon content. Addressing this distinct feature, it is possible to hit upon the carbon distribution along the sequence and can easily recognize the stable nature of protein. There are certain reported mental disorders which fall in to this category. Regardless, such kind of disorder prone protein FMR1p (Fragile X mental retardation 1 protein) is identified as the main cause for the disease Fragile X syndrome. This paper deals with the identification of defects in the FMR1 protein sequence considering the carbon contents along the sequence. This attempt is to evaluate the stability of proteins, accordingly the protein disorders in order to improvise the certain Biological functions of proteins to prevent disease. The transition of the disorder to order protein involves careful considerations and can be achieved by detecting the unstable region that lacks hydrophobicity. This work focuses the low carbon content in the FMR1 protein so as to attain the stable status in future to reduce the morbidity rate caused by Fragile X syndrome for the society.
用碳组成评价FMR1蛋白的结构紊乱
从那时起,蛋白质紊乱是许多疾病的主要原因。与其他疾病相比,导致疾病的主要原因是许多蛋白质的结构失能。近期数据集的潜在可用性有助于人们发现蛋白质紊乱,但在大多数情况下,蛋白质的稳定性取决于碳含量。针对这一独特的特征,有可能击中沿序列的碳分布,可以很容易地识别蛋白质的稳定性。据报道,有一些精神障碍属于这一类。无论如何,这种易患疾病的蛋白FMR1p(脆性X智力迟钝1蛋白)被确定为导致脆性X综合征的主要原因。本文研究了基于碳含量的FMR1蛋白序列缺陷识别方法。这一尝试是评价蛋白质的稳定性,根据蛋白质的紊乱,以即兴发挥蛋白质的某些生物学功能来预防疾病。无序到有序蛋白质的转变需要仔细考虑,可以通过检测缺乏疏水性的不稳定区域来实现。本工作的重点是FMR1蛋白的低碳含量,以便在未来达到稳定的状态,为社会降低脆性X综合征的发病率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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