Enhancement of Gum Solubility by Single Process of Humidification and Drying (Granulation)

A. Sy, Nour Wf
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引用次数: 2

Abstract

Gum arabic is a complex, loose aggregate of sugars and hemicelluloses composed of Arabic acid nucleus connected with calcium, magnesium, potassium and sugars Arabinose, Galactose, and Rhamnose. It is found in mechanically ground or spray dried forms. The solubility varies between 2 h in the raw gum form and 20 min in spray dried form. This study tended to enhance the solubility by producing an instant soluble granulated form. The study was performed using atomized fluid bed drier. 50 kg of raw gum, subjected first to mechanical comminuting into powder, then treated with water by spraying at rate of 200 mL/min for 90 min. The inlet temperature was 70°C, and the outlet temperature was 40°C. The cabinet temperature was 40°C. Finally after water treatment process, the powder resized through Mesh size of 40 μm and the microbial test was done for the finished product. The solubility of the granulated instant soluble gum in room temperature was found to be less than 5 min compared to the spray dried form which is 20-30 min and 2 h for mechanical ground gum. The volume increased to three times compare to the mechanical form. It was concluded that granulation of gum under water spray significantly enhances the solubility and hence it is beneficial for uses in pharmaceutical technology. This study tended to produce a form of granulated gum which is easily soluble compared to the mechanically ground and spray dried forms.
湿干燥(造粒)单一工艺提高树胶溶解度
阿拉伯胶是一种复杂、松散的糖和半纤维素的集合体,由阿拉伯酸核与钙、镁、钾和糖(阿拉伯糖、半乳糖和鼠李糖)连接而成。它以机械研磨或喷雾干燥的形式存在。其溶解度在生胶形式下为2小时,在喷雾干燥形式下为20分钟。本研究倾向于通过生产可溶的颗粒状来提高溶解度。研究采用雾化流化床干燥机进行。生胶50 kg,先机械粉碎成粉末,再以200 mL/min的速度喷水处理90 min,进口温度70℃,出口温度40℃。机柜温度为40℃。最后经水处理工艺后,对粉体进行粒径为40 μm的调整,并对成品进行微生物试验。颗粒状速溶胶在室温下的溶解度小于5分钟,而喷雾干燥形式的溶解度为20-30分钟,机械磨碎胶为2小时。体积增加到机械形式的三倍。结果表明,胶在水喷雾下造粒可显著提高胶的溶解度,有利于胶在制药工艺中的应用。与机械研磨和喷雾干燥的形式相比,本研究倾向于生产一种易于溶解的颗粒状口香糖。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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