Murray Finkelstein, Clara M. Kromer, Sheila A. Sweeney, Charles S. Delahunt
{"title":"Some Aspects of the Pharmacology of Clemizole Hydrochloride*","authors":"Murray Finkelstein, Clara M. Kromer, Sheila A. Sweeney, Charles S. Delahunt","doi":"10.1002/jps.3030490107","DOIUrl":null,"url":null,"abstract":"<div><p>Experiments have been described which demonstrate effective prolonged antihistaminic activity and other aspects of the pharmacology of clemizole HC1 (1-<em>p</em>-chloro-benzyl-2-pyrrolidyl-methyl-benzimidazole hydrochloride). A relatively high degree of antihistaminic specificity was observed in both <em>in vitro</em> and <em>in vivo</em> experiments. Clemizole was highly effective in antagonizing histamine aerosol bronchospasm. Spontaneous activity of isolated rabbit ileum and intestinal motility in anesthetized dogs were decreased. There was no significant effect on histamine-induced gastric secretion in chronic gastric fistula dogs. Enhanced responses to epinephrine appear to be due to a sensitization to this amine by the antihistamine.</p><p>Acute and chronic studies showed a relatively low order of toxicity.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 1","pages":"Pages 18-22"},"PeriodicalIF":0.0000,"publicationDate":"1960-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490107","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0095955315360844","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 16
Abstract
Experiments have been described which demonstrate effective prolonged antihistaminic activity and other aspects of the pharmacology of clemizole HC1 (1-p-chloro-benzyl-2-pyrrolidyl-methyl-benzimidazole hydrochloride). A relatively high degree of antihistaminic specificity was observed in both in vitro and in vivo experiments. Clemizole was highly effective in antagonizing histamine aerosol bronchospasm. Spontaneous activity of isolated rabbit ileum and intestinal motility in anesthetized dogs were decreased. There was no significant effect on histamine-induced gastric secretion in chronic gastric fistula dogs. Enhanced responses to epinephrine appear to be due to a sensitization to this amine by the antihistamine.
Acute and chronic studies showed a relatively low order of toxicity.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
