Articles of Significant Interest Selected from This Issue by the Editors

Abstract

and dendritic cell the repertoire of natural MDP ligands by the and increased fitness for intestinal colonization. Analysis of published genomic data reveals that positive selection for nucleotide polymorphisms in virulence-associated genes may have con-tributed to emergence of a hypervirulent clone that then spread globally, bringing attention to how single nucleotide changes can dramatically affect pathogenic potential and pandemic spread.