N. Sakiyama, R. Ke, R. Sawada, M. Sonoyama, S. Mitaku
{"title":"Nuclear proteins with charge periodicity of 28 residues are specifically increased in vertebrate genomes","authors":"N. Sakiyama, R. Ke, R. Sawada, M. Sonoyama, S. Mitaku","doi":"10.1273/CBIJ.7.69","DOIUrl":null,"url":null,"abstract":"More than 36,000 open reading frames (ORFs) from the human genome were previously analyzed by the autocorrelation function of electric charge distribution, revealing the existence of many proteins with a charge periodicity of 28 residues (PCP28) (Ke et al., Jpn. J. Appl. Phys. 2007). The major component of PCP28 was located in the nucleus, and the nuclear PCP28 of ten vertebrate and seven invertebrate organisms were predicted with a novel software system (Sakiyama et al., CBI Journal 2007) for revealing the biological significance of nuclear PCP28. Retrieval of the features of the human nuclear PCP28 in Swiss-Prot revealed that almost 90% of nuclear PCP28 functions in transcriptional regulation, including hypothetical transcription factors. To study how nuclear PCP28 is increased in eukaryote genomes, we compared the number of all nuclear PCP28 in vertebrate and invertebrate genomes. The results showed that nuclear PCP28 is specifically increased in vertebrate genomes and that the ratio of other types of PCP28 is almost constant in all eukaryote genomes. These findings strongly suggest that nuclear PCP28 is an essential protein for vertebrate organisms.","PeriodicalId":40659,"journal":{"name":"Chem-Bio Informatics Journal","volume":"29 1","pages":"69-78"},"PeriodicalIF":0.4000,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chem-Bio Informatics Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1273/CBIJ.7.69","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
More than 36,000 open reading frames (ORFs) from the human genome were previously analyzed by the autocorrelation function of electric charge distribution, revealing the existence of many proteins with a charge periodicity of 28 residues (PCP28) (Ke et al., Jpn. J. Appl. Phys. 2007). The major component of PCP28 was located in the nucleus, and the nuclear PCP28 of ten vertebrate and seven invertebrate organisms were predicted with a novel software system (Sakiyama et al., CBI Journal 2007) for revealing the biological significance of nuclear PCP28. Retrieval of the features of the human nuclear PCP28 in Swiss-Prot revealed that almost 90% of nuclear PCP28 functions in transcriptional regulation, including hypothetical transcription factors. To study how nuclear PCP28 is increased in eukaryote genomes, we compared the number of all nuclear PCP28 in vertebrate and invertebrate genomes. The results showed that nuclear PCP28 is specifically increased in vertebrate genomes and that the ratio of other types of PCP28 is almost constant in all eukaryote genomes. These findings strongly suggest that nuclear PCP28 is an essential protein for vertebrate organisms.
先前通过电荷分布的自相关函数分析了来自人类基因组的36000多个开放阅读框(orf),揭示了许多具有28个残基(PCP28)电荷周期的蛋白质的存在(Ke et al., Jpn.)。j:。物理,2007)。PCP28的主要成分位于细胞核中,利用一种新颖的软件系统对10种脊椎动物和7种无脊椎动物的核PCP28进行了预测(Sakiyama et al., CBI Journal 2007),揭示了核PCP28的生物学意义。在Swiss-Prot中检索人类核PCP28的特征显示,几乎90%的核PCP28在转录调控中起作用,包括假设的转录因子。为了研究核PCP28如何在真核生物基因组中增加,我们比较了脊椎动物和无脊椎动物基因组中所有核PCP28的数量。结果表明,核PCP28在脊椎动物基因组中特异性增加,而其他类型的PCP28在所有真核生物基因组中的比例几乎不变。这些发现有力地表明核PCP28是脊椎动物必不可少的蛋白质。