Abstract IA10: PMN-MDSC and neutrophils: Tale of two cells in cancer

Tackling the Tumor Microenvironment: Beyond T-cells Pub Date : 2019-02-01 DOI:10.1158/2326-6074.CRICIMTEATIAACR18-IA10

D. Gabrilovich

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Abstract

Myeloid cells are a critical component of the tumor microenvironment. In cancer, the myeloid compartment is dramatically affected, which is now considered as one of the major immunological hallmarks of cancer. Accumulation of immunosuppressive macrophages (MΦ), defective dendritic cells (DC) function and expansion of pathologically activated immune suppressive immature myeloid cells – myeloid-derived suppressor cells (MDSC) are major changes in the myeloid compartment in cancer. The total population of MDSC consists of three groups of cells: the most abundant (>75%) immature, pathologically activated neutrophils (PMN-MDSC); the less abundant population of pathologically activated monocytes – (M-MDSC). Tumor associated macrophages (TAM) and DCs can persist in tissues for a long time, whereas PMN-MDSC have short lifespan ( Citation Format: Dmitry I. Gabrilovich. PMN-MDSC and neutrophils: Tale of two cells in cancer [abstract]. In: Proceedings of the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; Sept 30-Oct 3, 2018; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2019;7(2 Suppl):Abstract nr IA10.

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摘要:PMN-MDSC和中性粒细胞:肿瘤中两种细胞的故事

骨髓细胞是肿瘤微环境的重要组成部分。在癌症中，髓细胞室受到显著影响，这被认为是癌症的主要免疫学标志之一。免疫抑制性巨噬细胞(MΦ)的积累、树突状细胞(DC)功能的缺陷和病理激活的免疫抑制性未成熟骨髓细胞-髓源性抑制细胞(MDSC)的扩增是癌症骨髓腔室的主要变化。MDSC的总细胞群由三组细胞组成:最丰富的(>75%)未成熟的、病理活化的中性粒细胞(PMN-MDSC);较少数量的病理活化单核细胞(M-MDSC)。肿瘤相关巨噬细胞(Tumor associated macrophages, TAM)和dc可在组织中存活较长时间，而PMN-MDSC寿命较短(Citation Format: Dmitry I. Gabrilovich)。PMN-MDSC和中性粒细胞:肿瘤中两种细胞的故事[摘要]。第四届CRI-CIMT-EATI-AACR国际癌症免疫治疗会议:将科学转化为生存;2018年9月30日至10月3日;纽约，纽约。费城(PA): AACR;癌症免疫学杂志2019;7(2增刊):摘要1 - 10。

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Tackling the Tumor Microenvironment: Beyond T-cells

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