Design, Development and Evaluation Of Anti-Hypertensive Drug Solid Lipid Nano Particles

American Journal of PharmTech Research Pub Date : 2021-08-07 DOI:10.46624/ajptr.2021.v11.i4.006

R. Chethan, P. Ashokkumar

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Abstract

Recently, solid lipid Nano-particles have received much attention by the researchers owing to its biodegradability, biocompatibility and the ability to deliver a wide range of drugs. The aim of the present study was to design Diltiazem solid lipid Nano-particles and to evaluate them. Diltiazem solid lipid Nano-particles were prepared by hot homogenization technique using different lipids (Tristearin, GMS and Comprital), soy lecithin as stabilizers and tween 80, Poloxamer as surfactants. The Nano-particles were evaluated for particle size & PDI, zeta potential, entrapment efficiency and in vitro drug release. The particle size ranged from 49.7 to 523.7 nm. PDI of all formulations were good within the range of 0.189 to 0.427. The zeta potential ranged from -10.5 to -29.6 Mv, Entrapment efficiency of all formulations were observed was in the range of 78.68 to 95.23 %. The cumulative percentage release of Diltiazem from different Diltiazem Nano-particles varied from 53.36 to 88.74% depending upon the drug lipid ratio and the type of lipid used. The average percentage of drug released from different SLNs after 24 hours showed in the following order: F9 (53.35%) < F6 (56.75%) < F4 (61.74%) < F7 (63.8%) < F5(67.77%) < F8(69.04%) < F3(75.31%) < F1(79.36%)

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抗高血压药物固体脂质纳米颗粒的设计、研制与评价

近年来，固体脂质纳米颗粒因其生物可降解性、生物相容性和广泛的药物递送能力而受到研究人员的广泛关注。本研究的目的是设计地尔硫卓固体脂质纳米颗粒并对其进行评价。采用热均质技术，以不同脂质(Tristearin、GMS和Comprital)、大豆卵磷脂为稳定剂、tween 80、poloxomer为表面活性剂制备了地尔硫卓固体脂质纳米颗粒。对纳米颗粒的粒径、PDI、zeta电位、包封效率和体外药物释放度进行了评价。粒径范围为49.7 ~ 523.7 nm。各配方的PDI在0.189 ~ 0.427范围内均较好。zeta电位范围为-10.5 ~ -29.6 Mv，包封率为78.68% ~ 95.23%。不同的地尔硫卓纳米颗粒对地尔硫卓的累积释放百分比根据药物脂质比和所使用的脂质类型而变化，从53.36%到88.74%不等。24 h后不同sln的平均释药率依次为:F9 (53.35%) < F6 (56.75%) < F4 (61.74%) < F7 (63.8%) < F5(67.77%) < F8(69.04%) < F3(75.31%) < F1(79.36%)

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American Journal of PharmTech Research

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