ApaI polymorphisms of the vitamin D receptor predict bone density of the lumbar spine and not racial difference in bone density in young men.

N. Bell, N. Morrison, Tuan V. Nguyen, J. Eisman, B. Hollis
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引用次数: 33

Abstract

A number of previous investigations showed significant associations between polymorphisms of the vitamin D receptor (VDR) gene and bone mineral density (BMD). BMD is influenced by hormones and the rate of skeletal remodeling. A study was performed to investigate the possible relationship between Apa I, Bsm I, Taq I, and Fok I polymorphisms of the VDR gene and serum 1,25-dihydroxyvitamin D (1,25[OH]2D), osteocalcin, and propeptide of type I collagen (PICP)-markers of bone turnover, total body calcium, and BMD of the total body, radius, lumbar spine, trochanter, and femoral neck-in 39 young adult black men of 20 to 40 years of age and 44 age-, height-, and weight-matched white men. The distribution of each of the four alleles of the VDR genotypes was similar in the two racial groups. The Apa I VDR genotype was associated with serum PICP (P =.0494) but not with serum 1,25(OH)2D or serum osteocalcin. A significant association between the Apa I VDR genotype and BMD of the lumbar spine (P =.0291) was also observed. However, the Bsm I, Taq I, and Fok I genotypes were not significantly associated with BMD or serum osteocalcin, PICP, or 1,25(OH)2D. Multivariate stepwise analysis indicated that (1) the Apa I VDR genotype was associated with BMD of the lumbar spine in the two groups together; with total body calcium and BMD of the total body, radius, trochanter, and femoral neck in the black men; and with BMD of the radius in the white men; analysis also indicated that (2) race was significantly associated with total body calcium and BMD of the total body, lumbar spine, and femoral neck. In summary, the Apa I VDR genotype is associated with serum PICP and BMD at a number of sites but does not contribute to or account for racial differences in BMD in young adult men.
维生素D受体ApaI多态性预测腰椎骨密度,而不是年轻男性骨密度的种族差异。
先前的一些研究表明,维生素D受体(VDR)基因多态性与骨矿物质密度(BMD)之间存在显著关联。骨密度受激素和骨骼重塑速率的影响。进行的一项研究调查Apa我之间可能的关系,Bsm, Taq我,霍英东我VDR基因多态性和血清1,25-dihydroxyvitamin D(1,25(哦)2 D)、骨钙素,和前肽的I型胶原蛋白(PICP)标记的骨代谢,全身钙,和全身的骨密度,半径,腰椎,转子,和股骨的39个年轻人20到40岁的黑人男性,44岁,身高,和weight-matched白人。VDR基因型的4个等位基因在两个种族群体中的分布相似。Apa I VDR基因型与血清PICP相关(P = 0.0494),但与血清1,25(OH)2D或血清骨钙素无关。Apa I VDR基因型与腰椎骨密度有显著相关性(P = 0.0291)。然而,Bsm I、Taq I和Fok I基因型与BMD或血清骨钙素、PICP或1,25(OH)2D没有显著相关。多因素逐步分析表明:(1)Apa I VDR基因型与两组腰椎骨密度均相关;黑人男性的全身、桡骨、粗隆和股骨颈的总钙和骨密度;与白人的桡骨骨密度有关;分析还表明(2)种族与全身、腰椎和股骨颈的总钙和骨密度显著相关。总之,Apa I VDR基因型在许多位点与血清PICP和骨密度相关,但不能解释年轻成年男性骨密度的种族差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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