Studies on the activity of obioactin with acetylspiramycin on mice infected with toxoplasma gondii

Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious... Pub Date : 1984-03-01 DOI:10.1016/S0174-3031(84)80015-3

Naoyoshi Suzuki , Fem M. Espinas , Haruhisa Sakurai , Atsushi Saito , Hiroshi Sasaki , Gunshiro Kato , Koichi Manba , Kazuyuki Taniguchi , Koshi Mochizuki , Humio Osaki

{"title":"Studies on the activity of obioactin with acetylspiramycin on mice infected with toxoplasma gondii","authors":"Naoyoshi Suzuki , Fem M. Espinas , Haruhisa Sakurai , Atsushi Saito , Hiroshi Sasaki , Gunshiro Kato , Koichi Manba , Kazuyuki Taniguchi , Koshi Mochizuki , Humio Osaki","doi":"10.1016/S0174-3031(84)80015-3","DOIUrl":null,"url":null,"abstract":"<div><p>In acutely infected mice, acetylspiramycin (ASPM) administered in combination with Obioactin, or sulfamethoxypyrazine (SMPZ), prevented <em>Toxoplasma</em> organisms from encysting in the brain and heart tissues. When adminstered alone, ASPM prevented these organisms from encysting in the heart but not in the brain.</p><p>All the regimens used failed to reduce the bulk of parasites in the brain and heart tissues of chronically infected mice. Treatment with an ASPM-Obioactin combination, however, brought about the most remarkable reduction, or 52.4 %, of the cyst count in the brain of all the methods of treatment applied. Light and electron microscopy of the mice with chronic <em>Toxoplasma</em> infection revealed no changes in the brain or heart tissue of the ASPM-Obioactin treated mice and degenerative changes in the cyst wall and bradyzoites and a remarkable increase of microglias with cysts in the brain in some of these mice.</p></div>","PeriodicalId":79282,"journal":{"name":"Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...","volume":"256 3","pages":"Pages 367-380"},"PeriodicalIF":0.0000,"publicationDate":"1984-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0174-3031(84)80015-3","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0174303184800153","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 3

Abstract

In acutely infected mice, acetylspiramycin (ASPM) administered in combination with Obioactin, or sulfamethoxypyrazine (SMPZ), prevented Toxoplasma organisms from encysting in the brain and heart tissues. When adminstered alone, ASPM prevented these organisms from encysting in the heart but not in the brain.

All the regimens used failed to reduce the bulk of parasites in the brain and heart tissues of chronically infected mice. Treatment with an ASPM-Obioactin combination, however, brought about the most remarkable reduction, or 52.4 %, of the cyst count in the brain of all the methods of treatment applied. Light and electron microscopy of the mice with chronic Toxoplasma infection revealed no changes in the brain or heart tissue of the ASPM-Obioactin treated mice and degenerative changes in the cyst wall and bradyzoites and a remarkable increase of microglias with cysts in the brain in some of these mice.

查看原文本刊更多论文

生物肌动蛋白与乙酰螺旋霉素对刚地弓形虫感染小鼠的活性研究

在急性感染小鼠中，乙酰螺旋霉素(ASPM)与Obioactin或磺胺甲氧基吡嗪(SMPZ)联合使用，可以防止弓形虫有机体在大脑和心脏组织中形成囊状。当单独给药时，ASPM能阻止这些有机体在心脏内淤积，但不能阻止它们在大脑内淤积。所有使用的治疗方案都未能减少慢性感染小鼠大脑和心脏组织中的寄生虫数量。然而，在所有治疗方法中，ASPM-Obioactin联合治疗带来了最显著的减少，即脑部囊肿计数减少52.4%。慢性弓形虫感染小鼠的光镜和电镜显示，ASPM-Obioactin治疗小鼠的大脑或心脏组织没有变化，囊肿壁和慢殖子发生退行性变化，其中一些小鼠的脑内囊肿小胶质细胞显著增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...

自引率

0.00%

发文量